Telomerase and Therapy of Brain Tumors
Telomere is a special structure protects the ends of human chromosomes to degrade. Telomere becomes shorter after each cycle of cell division. However, telomerase is an enzyme activated in cancer cells and germ lines rebuild telomere. However, apparently there is no correlation between telomere leng...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3559 |
| _version_ | 1827843995810660352 |
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| author | Majid Kheirollahi Roya Khajeh-Goodari Reza Ghavimi |
| author_facet | Majid Kheirollahi Roya Khajeh-Goodari Reza Ghavimi |
| author_sort | Majid Kheirollahi |
| collection | DOAJ |
| description | Telomere is a special structure protects the ends of human chromosomes to degrade. Telomere becomes shorter after each cycle of cell division. However, telomerase is an enzyme activated in cancer cells and germ lines rebuild telomere. However, apparently there is no correlation between telomere length and telomerase activity. The enzymatic activity of telomerase correlates with tumor malignancy. In general, telomerase activity and histological grade are too closely correlated and the results of studies indicate that telomerase activity may be an important malignancy marker in brain tumors. As a conclusion, we can say that activity of telomerase should be considered as a prognostic biological marker of response to treatment. |
| first_indexed | 2024-03-12T08:34:58Z |
| format | Article |
| id | doaj.art-8cd30d5bbcc348358b887b50be70dfff |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:34:58Z |
| publishDate | 2014-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-8cd30d5bbcc348358b887b50be70dfff2023-09-02T17:18:08ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-03-0131267219322081496Telomerase and Therapy of Brain TumorsMajid Kheirollahi0Roya Khajeh-Goodari1Reza Ghavimi2Assistant Professor, Pediatrics Inherited Diseases Research Center AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Department of Genetics and Molecular Biology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Department of Genetics and Molecular Biology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranTelomere is a special structure protects the ends of human chromosomes to degrade. Telomere becomes shorter after each cycle of cell division. However, telomerase is an enzyme activated in cancer cells and germ lines rebuild telomere. However, apparently there is no correlation between telomere length and telomerase activity. The enzymatic activity of telomerase correlates with tumor malignancy. In general, telomerase activity and histological grade are too closely correlated and the results of studies indicate that telomerase activity may be an important malignancy marker in brain tumors. As a conclusion, we can say that activity of telomerase should be considered as a prognostic biological marker of response to treatment.http://jims.mui.ac.ir/index.php/jims/article/view/3559TelomeraseTherapyBrain tumors |
| spellingShingle | Majid Kheirollahi Roya Khajeh-Goodari Reza Ghavimi Telomerase and Therapy of Brain Tumors مجله دانشکده پزشکی اصفهان Telomerase Therapy Brain tumors |
| title | Telomerase and Therapy of Brain Tumors |
| title_full | Telomerase and Therapy of Brain Tumors |
| title_fullStr | Telomerase and Therapy of Brain Tumors |
| title_full_unstemmed | Telomerase and Therapy of Brain Tumors |
| title_short | Telomerase and Therapy of Brain Tumors |
| title_sort | telomerase and therapy of brain tumors |
| topic | Telomerase Therapy Brain tumors |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3559 |
| work_keys_str_mv | AT majidkheirollahi telomeraseandtherapyofbraintumors AT royakhajehgoodari telomeraseandtherapyofbraintumors AT rezaghavimi telomeraseandtherapyofbraintumors |