A Quick Guide to CAF Subtypes in Pancreatic Cancer
Pancreatic cancer represents one of the most desmoplastic malignancies and is characterized by an extensive deposition of extracellular matrix. The latter is provided by activated cancer-associated fibroblasts (CAFs), which are abundant cells in the pancreatic tumor microenvironment. Many recent stu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/9/2614 |
| _version_ | 1797602852059742208 |
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| author | Anna Brichkina Pierfrancesco Polo Shrey Dharamvir Sharma Nico Visestamkul Matthias Lauth |
| author_facet | Anna Brichkina Pierfrancesco Polo Shrey Dharamvir Sharma Nico Visestamkul Matthias Lauth |
| author_sort | Anna Brichkina |
| collection | DOAJ |
| description | Pancreatic cancer represents one of the most desmoplastic malignancies and is characterized by an extensive deposition of extracellular matrix. The latter is provided by activated cancer-associated fibroblasts (CAFs), which are abundant cells in the pancreatic tumor microenvironment. Many recent studies have made it clear that CAFs are not a singular cellular entity but represent a multitude of potentially dynamic subgroups that affect tumor biology at several levels. As mentioned before, CAFs significantly contribute to the fibrotic reaction and the biomechanical properties of the tumor, but they can also modulate the local immune environment and the response to targeted, chemo or radiotherapy. As the number of known and emerging CAF subgroups is steadily increasing, it is becoming increasingly difficult to keep up with these developments and to clearly discriminate the cellular subsets identified so far. This review aims to provide a helpful overview that enables readers to quickly familiarize themselves with field of CAF heterogeneity and to grasp the phenotypic, functional and therapeutic distinctions of the various stromal subpopulations. |
| first_indexed | 2024-03-11T04:22:23Z |
| format | Article |
| id | doaj.art-8cd61f1fc68646da8ee79ca6ebf7c3c5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:22:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8cd61f1fc68646da8ee79ca6ebf7c3c52023-11-17T22:42:10ZengMDPI AGCancers2072-66942023-05-01159261410.3390/cancers15092614A Quick Guide to CAF Subtypes in Pancreatic CancerAnna Brichkina0Pierfrancesco Polo1Shrey Dharamvir Sharma2Nico Visestamkul3Matthias Lauth4Center for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Hans-Meerwein-Str. 3, 35043 Marburg, GermanyCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Hans-Meerwein-Str. 3, 35043 Marburg, GermanyCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Hans-Meerwein-Str. 3, 35043 Marburg, GermanyCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Hans-Meerwein-Str. 3, 35043 Marburg, GermanyCenter for Tumor and Immune Biology, Clinics for Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Hans-Meerwein-Str. 3, 35043 Marburg, GermanyPancreatic cancer represents one of the most desmoplastic malignancies and is characterized by an extensive deposition of extracellular matrix. The latter is provided by activated cancer-associated fibroblasts (CAFs), which are abundant cells in the pancreatic tumor microenvironment. Many recent studies have made it clear that CAFs are not a singular cellular entity but represent a multitude of potentially dynamic subgroups that affect tumor biology at several levels. As mentioned before, CAFs significantly contribute to the fibrotic reaction and the biomechanical properties of the tumor, but they can also modulate the local immune environment and the response to targeted, chemo or radiotherapy. As the number of known and emerging CAF subgroups is steadily increasing, it is becoming increasingly difficult to keep up with these developments and to clearly discriminate the cellular subsets identified so far. This review aims to provide a helpful overview that enables readers to quickly familiarize themselves with field of CAF heterogeneity and to grasp the phenotypic, functional and therapeutic distinctions of the various stromal subpopulations.https://www.mdpi.com/2072-6694/15/9/2614tumor stromapancreatic cancercancer-associated fibroblastCAFstellate cellECM |
| spellingShingle | Anna Brichkina Pierfrancesco Polo Shrey Dharamvir Sharma Nico Visestamkul Matthias Lauth A Quick Guide to CAF Subtypes in Pancreatic Cancer Cancers tumor stroma pancreatic cancer cancer-associated fibroblast CAF stellate cell ECM |
| title | A Quick Guide to CAF Subtypes in Pancreatic Cancer |
| title_full | A Quick Guide to CAF Subtypes in Pancreatic Cancer |
| title_fullStr | A Quick Guide to CAF Subtypes in Pancreatic Cancer |
| title_full_unstemmed | A Quick Guide to CAF Subtypes in Pancreatic Cancer |
| title_short | A Quick Guide to CAF Subtypes in Pancreatic Cancer |
| title_sort | quick guide to caf subtypes in pancreatic cancer |
| topic | tumor stroma pancreatic cancer cancer-associated fibroblast CAF stellate cell ECM |
| url | https://www.mdpi.com/2072-6694/15/9/2614 |
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