Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis
IntroductionChronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330386/full |
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| author | Anna Tylutka Łukasz Walas Agnieszka Zembron-Lacny |
| author_facet | Anna Tylutka Łukasz Walas Agnieszka Zembron-Lacny |
| author_sort | Anna Tylutka |
| collection | DOAJ |
| description | IntroductionChronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature.MethodsThe electronic bibliographic PubMed database was systematically searched to select all the relevant studies published up to July 2023. The total number of the subjects involved in the meta-analysis included patients with diseases (n=8154) and controls (n=33967).ResultsThe overall concentration of IL-6 was found to be higher in patients with diseases compared to controls and the difference was statistically significant, with a p-value of <0.001 (SMD, 0.16; 95% CI, 0.12–0.19). The heterogeneity was considerable with Q = 109.97 (P <0.0001) and I2 = 79.2%. The potential diagnostic usefulness of IL-6 was confirmed by odds ratio (OR) analysis (OR: 1.03, 95% CI (1.01; 1.05), p=0.0029). The concentration of both TNF and IL-1β was elevated in the control group compared to patients and amounted to SMD -0.03; 95% CI, -0.09–0.02, p-value 0.533 and SMD-0.29; 95% CI, -0.47– -0.12; p = 0.001, respectively. For TNF, however, the difference was statistically insignificant.DiscussionIL-6, unlike TNF and IL-1β, could be a useful and convenient marker of peripheral inflammation in older adults with various comorbidities. |
| first_indexed | 2024-03-07T19:10:31Z |
| format | Article |
| id | doaj.art-8cd7007ae3d8475587f5aa0cebbf50a5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T19:10:31Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8cd7007ae3d8475587f5aa0cebbf50a52024-03-01T04:45:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13303861330386Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysisAnna Tylutka0Łukasz Walas1Agnieszka Zembron-Lacny2Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Zielona Gora, PolandInstitute of Dendrology, Polish Academy of Sciences, Kórnik, PolandDepartment of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Zielona Gora, PolandIntroductionChronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature.MethodsThe electronic bibliographic PubMed database was systematically searched to select all the relevant studies published up to July 2023. The total number of the subjects involved in the meta-analysis included patients with diseases (n=8154) and controls (n=33967).ResultsThe overall concentration of IL-6 was found to be higher in patients with diseases compared to controls and the difference was statistically significant, with a p-value of <0.001 (SMD, 0.16; 95% CI, 0.12–0.19). The heterogeneity was considerable with Q = 109.97 (P <0.0001) and I2 = 79.2%. The potential diagnostic usefulness of IL-6 was confirmed by odds ratio (OR) analysis (OR: 1.03, 95% CI (1.01; 1.05), p=0.0029). The concentration of both TNF and IL-1β was elevated in the control group compared to patients and amounted to SMD -0.03; 95% CI, -0.09–0.02, p-value 0.533 and SMD-0.29; 95% CI, -0.47– -0.12; p = 0.001, respectively. For TNF, however, the difference was statistically insignificant.DiscussionIL-6, unlike TNF and IL-1β, could be a useful and convenient marker of peripheral inflammation in older adults with various comorbidities.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330386/fullcomorbiditiesimmunosenescenceinterleukin 1βinterleukin 6tumor necrosis factor |
| spellingShingle | Anna Tylutka Łukasz Walas Agnieszka Zembron-Lacny Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis Frontiers in Immunology comorbidities immunosenescence interleukin 1β interleukin 6 tumor necrosis factor |
| title | Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis |
| title_full | Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis |
| title_fullStr | Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis |
| title_full_unstemmed | Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis |
| title_short | Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis |
| title_sort | level of il 6 tnf and il 1β and age related diseases a systematic review and meta analysis |
| topic | comorbidities immunosenescence interleukin 1β interleukin 6 tumor necrosis factor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330386/full |
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