Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis

Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis

Macroautophagy (or autophagy) is a conserved cellular process in which cytoplasmic cargo is targeted for lysosomal degradation. Autophagy is crucial for the functional integrity of different subsets of T cells in various developmental stages. Since atherosclerosis is an inflammatory disease of the v...

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Bibliographic Details
Main Authors: Jacob Amersfoort, Hidde Douna, Frank H. Schaftenaar, Amanda C. Foks, Mara J. Kröner, Peter J. van Santbrink, Gijs H. M. van Puijvelde, Ilze Bot, Johan Kuiper
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
autophagy
Atg7
T cells
steatosis
atherosclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02937/full

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