C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
Since its introduction as a genetic model organism, Caenorhabditis elegans has yielded insights into the causes of aging. In addition, it has provided a molecular understanding of mechanisms of neurodegeneration, one of the devastating effects of aging. However, C. elegans has been less popular as a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.916118/full |
| _version_ | 1818216986782466048 |
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| author | Francisco José Naranjo-Galindo Francisco José Naranjo-Galindo Ruixue Ai Evandro Fei Fang Hilde Loge Nilsen Hilde Loge Nilsen Hilde Loge Nilsen Tanima SenGupta Tanima SenGupta |
| author_facet | Francisco José Naranjo-Galindo Francisco José Naranjo-Galindo Ruixue Ai Evandro Fei Fang Hilde Loge Nilsen Hilde Loge Nilsen Hilde Loge Nilsen Tanima SenGupta Tanima SenGupta |
| author_sort | Francisco José Naranjo-Galindo |
| collection | DOAJ |
| description | Since its introduction as a genetic model organism, Caenorhabditis elegans has yielded insights into the causes of aging. In addition, it has provided a molecular understanding of mechanisms of neurodegeneration, one of the devastating effects of aging. However, C. elegans has been less popular as an animal model to investigate DNA repair and genomic instability, which is a major hallmark of aging and also a cause of many rare neurological disorders. This article provides an overview of DNA repair pathways in C. elegans and the impact of DNA repair on aging hallmarks, such as mitochondrial dysfunction, telomere maintenance, and autophagy. In addition, we discuss how the combination of biological characteristics, new technical tools, and the potential of following precise phenotypic assays through a natural life-course make C. elegans an ideal model organism to study how DNA repair impact neurodegeneration in models of common age-related neurodegenerative diseases. |
| first_indexed | 2024-12-12T07:00:41Z |
| format | Article |
| id | doaj.art-8cd9ee72575047619756f7ac32b7d610 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-12-12T07:00:41Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-8cd9ee72575047619756f7ac32b7d6102022-12-22T00:33:51ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-06-01310.3389/fragi.2022.916118916118C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and NeurodegenerationFrancisco José Naranjo-Galindo0Francisco José Naranjo-Galindo1Ruixue Ai2Evandro Fei Fang3Hilde Loge Nilsen4Hilde Loge Nilsen5Hilde Loge Nilsen6Tanima SenGupta7Tanima SenGupta8Department of Clinical Molecular Biology, University of Oslo, Oslo, NorwaySection of Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, NorwayDepartment of Clinical Molecular Biology, University of Oslo, Oslo, NorwayDepartment of Clinical Molecular Biology, University of Oslo, Oslo, NorwayDepartment of Clinical Molecular Biology, University of Oslo, Oslo, NorwaySection of Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, NorwayDepartment of Microbiology, Oslo University Hospital, Oslo, NorwayDepartment of Clinical Molecular Biology, University of Oslo, Oslo, NorwaySection of Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, NorwaySince its introduction as a genetic model organism, Caenorhabditis elegans has yielded insights into the causes of aging. In addition, it has provided a molecular understanding of mechanisms of neurodegeneration, one of the devastating effects of aging. However, C. elegans has been less popular as an animal model to investigate DNA repair and genomic instability, which is a major hallmark of aging and also a cause of many rare neurological disorders. This article provides an overview of DNA repair pathways in C. elegans and the impact of DNA repair on aging hallmarks, such as mitochondrial dysfunction, telomere maintenance, and autophagy. In addition, we discuss how the combination of biological characteristics, new technical tools, and the potential of following precise phenotypic assays through a natural life-course make C. elegans an ideal model organism to study how DNA repair impact neurodegeneration in models of common age-related neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fragi.2022.916118/fullagingneurodegenerative diseasesDNA repairParkinson’s diseaseCaenorhabditis elegansAlzheimer’s disease |
| spellingShingle | Francisco José Naranjo-Galindo Francisco José Naranjo-Galindo Ruixue Ai Evandro Fei Fang Hilde Loge Nilsen Hilde Loge Nilsen Hilde Loge Nilsen Tanima SenGupta Tanima SenGupta C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration Frontiers in Aging aging neurodegenerative diseases DNA repair Parkinson’s disease Caenorhabditis elegans Alzheimer’s disease |
| title | C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration |
| title_full | C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration |
| title_fullStr | C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration |
| title_full_unstemmed | C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration |
| title_short | C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration |
| title_sort | c elegans as an animal model to study the intersection of dna repair aging and neurodegeneration |
| topic | aging neurodegenerative diseases DNA repair Parkinson’s disease Caenorhabditis elegans Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.916118/full |
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