Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy
Acute myeloid leukemia (AML) is a heterogeneous disease with multiple mutations in hematopoietic stem cells characterized by abnormality increases in immature or dysfunctional white blood cells. The precise mechanisms of AML development have not been clear but there are many factors increase to dev...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2023-09-01
|
| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/573 |
| _version_ | 1797658914966208512 |
|---|---|
| author | Azzam Abdulsattar Mosa Ghorbat Saleh Ali Zeliha Selamoglu |
| author_facet | Azzam Abdulsattar Mosa Ghorbat Saleh Ali Zeliha Selamoglu |
| author_sort | Azzam Abdulsattar Mosa |
| collection | DOAJ |
| description |
Acute myeloid leukemia (AML) is a heterogeneous disease with multiple mutations in hematopoietic stem cells characterized by abnormality increases in immature or dysfunctional white blood cells. The precise mechanisms of AML development have not been clear but there are many factors increase to developing leukemia such as familial history of leukemia, elderly, life style, genetics and some chronic disease like diabetic. Multiple mutilations happen in the hematopoietic stem cells, acquire some form of genetic instability lead to improve expression of some protein kinase and transduction protein following that increase ROS formation, which is associated with increased DNA damage. Nowadays, the use antioxidant drugs are growingly accepted in universal due to their safety and efficiency to diminish the adverse effects of free radicals and treatment of the many diseases such as cancer. In this article, we discussed the correlation between acute myeloid leukemia incidence and the oxidant biomarkers (oxidative stress), and more focusing on the great role of antioxidant biomarkers, whether the non-enzymatic or the enzymatic in the protection of the cells against harmful effects of free radicals in the acute myeloid leukemia patients.
|
| first_indexed | 2024-03-11T18:06:18Z |
| format | Article |
| id | doaj.art-8cde7ed3ba174ad7ac6de7a11b7a9af9 |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-03-11T18:06:18Z |
| publishDate | 2023-09-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-8cde7ed3ba174ad7ac6de7a11b7a9af92023-10-17T05:30:43ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092023-09-01113Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia TherapyAzzam Abdulsattar Mosa0Ghorbat Saleh Ali1Zeliha Selamoglu2Department of Chemistry, Collage of Science, University of Duhok, Duhok, Iraq.Department of Biology, Collage of Science, University of Duhok, Duhok, Iraq.Nigde Ömer Halisdemir University Acute myeloid leukemia (AML) is a heterogeneous disease with multiple mutations in hematopoietic stem cells characterized by abnormality increases in immature or dysfunctional white blood cells. The precise mechanisms of AML development have not been clear but there are many factors increase to developing leukemia such as familial history of leukemia, elderly, life style, genetics and some chronic disease like diabetic. Multiple mutilations happen in the hematopoietic stem cells, acquire some form of genetic instability lead to improve expression of some protein kinase and transduction protein following that increase ROS formation, which is associated with increased DNA damage. Nowadays, the use antioxidant drugs are growingly accepted in universal due to their safety and efficiency to diminish the adverse effects of free radicals and treatment of the many diseases such as cancer. In this article, we discussed the correlation between acute myeloid leukemia incidence and the oxidant biomarkers (oxidative stress), and more focusing on the great role of antioxidant biomarkers, whether the non-enzymatic or the enzymatic in the protection of the cells against harmful effects of free radicals in the acute myeloid leukemia patients. https://jpc.tums.ac.ir/index.php/jpc/article/view/573Acute Myeloid Leukemia; Oxidative Stress; Antioxidant |
| spellingShingle | Azzam Abdulsattar Mosa Ghorbat Saleh Ali Zeliha Selamoglu Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy Journal of Pharmaceutical Care Acute Myeloid Leukemia; Oxidative Stress; Antioxidant |
| title | Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy |
| title_full | Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy |
| title_fullStr | Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy |
| title_full_unstemmed | Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy |
| title_short | Survey on the Oxidative Stress Status and the Role of Antioxidants in Acute Myeloid Leukemia Therapy |
| title_sort | survey on the oxidative stress status and the role of antioxidants in acute myeloid leukemia therapy |
| topic | Acute Myeloid Leukemia; Oxidative Stress; Antioxidant |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/573 |
| work_keys_str_mv | AT azzamabdulsattarmosa surveyontheoxidativestressstatusandtheroleofantioxidantsinacutemyeloidleukemiatherapy AT ghorbatsalehali surveyontheoxidativestressstatusandtheroleofantioxidantsinacutemyeloidleukemiatherapy AT zelihaselamoglu surveyontheoxidativestressstatusandtheroleofantioxidantsinacutemyeloidleukemiatherapy |