Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome
Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease and affects approximately half of the hypertensive population. While the precise mechanisms of salt-sensitivity remain unclear, recent findings on body sodium homeostasis and salt-induced immune cell activati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1096296/full |
| _version_ | 1797979316651294720 |
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| author | Lale A. Ertuglu Ashley Pitzer Mutchler Justin Yu Annet Kirabo |
| author_facet | Lale A. Ertuglu Ashley Pitzer Mutchler Justin Yu Annet Kirabo |
| author_sort | Lale A. Ertuglu |
| collection | DOAJ |
| description | Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease and affects approximately half of the hypertensive population. While the precise mechanisms of salt-sensitivity remain unclear, recent findings on body sodium homeostasis and salt-induced immune cell activation provide new insights into the relationship between high salt intake, inflammation, and hypertension. The immune system, specifically antigen-presenting cells (APCs) and T cells, are directly implicated in salt-induced renal and vascular injury and hypertension. Emerging evidence suggests that oxidative stress and activation of the NLRP3 inflammasome drive high sodium-mediated activation of APCs and T cells and contribute to the development of renal and vascular inflammation and hypertension. In this review, we summarize the recent insights into our understanding of the mechanisms of salt-sensitive hypertension and discuss the role of inflammasome activation as a potential therapeutic target. |
| first_indexed | 2024-04-11T05:37:06Z |
| format | Article |
| id | doaj.art-8cdecfcd993f4ce09aa579381ff225ad |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T05:37:06Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8cdecfcd993f4ce09aa579381ff225ad2022-12-22T11:01:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-12-011310.3389/fphys.2022.10962961096296Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasomeLale A. Ertuglu0Ashley Pitzer Mutchler1Justin Yu2Annet Kirabo3Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StaesDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United StatesDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesSalt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease and affects approximately half of the hypertensive population. While the precise mechanisms of salt-sensitivity remain unclear, recent findings on body sodium homeostasis and salt-induced immune cell activation provide new insights into the relationship between high salt intake, inflammation, and hypertension. The immune system, specifically antigen-presenting cells (APCs) and T cells, are directly implicated in salt-induced renal and vascular injury and hypertension. Emerging evidence suggests that oxidative stress and activation of the NLRP3 inflammasome drive high sodium-mediated activation of APCs and T cells and contribute to the development of renal and vascular inflammation and hypertension. In this review, we summarize the recent insights into our understanding of the mechanisms of salt-sensitive hypertension and discuss the role of inflammasome activation as a potential therapeutic target.https://www.frontiersin.org/articles/10.3389/fphys.2022.1096296/fullsalt sensitivityhypertensionimmunityinflammationinflammasome |
| spellingShingle | Lale A. Ertuglu Ashley Pitzer Mutchler Justin Yu Annet Kirabo Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome Frontiers in Physiology salt sensitivity hypertension immunity inflammation inflammasome |
| title | Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome |
| title_full | Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome |
| title_fullStr | Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome |
| title_full_unstemmed | Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome |
| title_short | Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome |
| title_sort | inflammation and oxidative stress in salt sensitive hypertension the role of the nlrp3 inflammasome |
| topic | salt sensitivity hypertension immunity inflammation inflammasome |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1096296/full |
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