A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis
Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/5/200 |
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| author | Francisco Alexandrino-Junior Kattya Gyselle de Holanda e Silva Marjorie Caroline Liberato Cavalcanti Freire Viviane de Oliveira Freitas Lione Elisama Azevedo Cardoso Henrique Rodrigues Marcelino Julieta Genre Anselmo Gomes de Oliveira Eryvaldo Sócrates Tabosa do Egito |
| author_facet | Francisco Alexandrino-Junior Kattya Gyselle de Holanda e Silva Marjorie Caroline Liberato Cavalcanti Freire Viviane de Oliveira Freitas Lione Elisama Azevedo Cardoso Henrique Rodrigues Marcelino Julieta Genre Anselmo Gomes de Oliveira Eryvaldo Sócrates Tabosa do Egito |
| author_sort | Francisco Alexandrino-Junior |
| collection | DOAJ |
| description | Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of <i>Leishmania</i> spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA−AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA−AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA−AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL. |
| first_indexed | 2024-04-11T21:41:14Z |
| format | Article |
| id | doaj.art-8cdff90da6ed4817a67c1f22b00bf6cf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T21:41:14Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8cdff90da6ed4817a67c1f22b00bf6cf2022-12-22T04:01:35ZengMDPI AGPharmaceutics1999-49232019-05-0111520010.3390/pharmaceutics11050200pharmaceutics11050200A Functional Wound Dressing as a Potential Treatment for Cutaneous LeishmaniasisFrancisco Alexandrino-Junior0Kattya Gyselle de Holanda e Silva1Marjorie Caroline Liberato Cavalcanti Freire2Viviane de Oliveira Freitas Lione3Elisama Azevedo Cardoso4Henrique Rodrigues Marcelino5Julieta Genre6Anselmo Gomes de Oliveira7Eryvaldo Sócrates Tabosa do Egito8Programa de Pós-Graduação em Nanotecnologia Farmacêutica (PPgNANOFARMA), Universidade Federal do Rio Grande do Norte (UFRN), Nata/RN 59012-570, BrazilFaculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ 21941-902, BrazilInstituto de Física de São Carlos, Universidade de São Paulo (USP), São Carlos/SP 13563-120, BrazilFaculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ 21941-902, BrazilFaculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ 21941-902, BrazilDepartamento do Medicamento, Universidade Federal da Bahia (UFBA), Salvador/BA 40170-115, BrazilFaculdade de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Nata/RN 59012-570, BrazilDepartamento de Fármacos e Medicamentos, Universidade Estadual Paulista (UNESP), Araraquara/SP 14800-903, BrazilPrograma de Pós-Graduação em Nanotecnologia Farmacêutica (PPgNANOFARMA), Universidade Federal do Rio Grande do Norte (UFRN), Nata/RN 59012-570, BrazilCutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of <i>Leishmania</i> spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA−AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA−AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA−AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.https://www.mdpi.com/1999-4923/11/5/200Amphotericin Bcutaneous leishmaniasishydrogelwound dressingcontrolled release |
| spellingShingle | Francisco Alexandrino-Junior Kattya Gyselle de Holanda e Silva Marjorie Caroline Liberato Cavalcanti Freire Viviane de Oliveira Freitas Lione Elisama Azevedo Cardoso Henrique Rodrigues Marcelino Julieta Genre Anselmo Gomes de Oliveira Eryvaldo Sócrates Tabosa do Egito A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis Pharmaceutics Amphotericin B cutaneous leishmaniasis hydrogel wound dressing controlled release |
| title | A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis |
| title_full | A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis |
| title_fullStr | A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis |
| title_full_unstemmed | A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis |
| title_short | A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis |
| title_sort | functional wound dressing as a potential treatment for cutaneous leishmaniasis |
| topic | Amphotericin B cutaneous leishmaniasis hydrogel wound dressing controlled release |
| url | https://www.mdpi.com/1999-4923/11/5/200 |
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