Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
Abstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92576-3 |
| _version_ | 1818845037937557504 |
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| author | Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff |
| author_facet | Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff |
| author_sort | Loni Berkowitz |
| collection | DOAJ |
| description | Abstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of middle-aged American adults (Midlife in the United States). Health behaviors (i.e., diet, exercise, and sleep) were also examined as potential mediators of these relationships. Serum levels of total ceramides—the main molecular class of sphingolipids previously associated with several disease conditions—were inversely linked with environmental mastery. In addition, significant correlations were found between specific ceramide, dihydroceramide, and hexosylceramides species with environmental mastery, purpose in life, and self-acceptance. Using hierarchical regression and mediation analyses, health behaviors appeared to mediate these associations. However, the link between ceramides and environmental mastery was partially independent of health behaviors, suggesting the role of additional mediating factors. These findings point to sphingolipid metabolism as a novel pathway of health benefits associated with psychological well-being. In particular, having a sense of environmental mastery may promote restorative behaviors and benefit health via improved blood sphingolipid profiles. |
| first_indexed | 2024-12-19T05:23:18Z |
| format | Article |
| id | doaj.art-8ce0699a67c14f34a15c1e3f29a0d7f5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:23:18Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8ce0699a67c14f34a15c1e3f29a0d7f52022-12-21T20:34:27ZengNature PortfolioScientific Reports2045-23222021-06-0111111110.1038/s41598-021-92576-3Association between serum sphingolipids and eudaimonic well-being in white U.S. adultsLoni Berkowitz0Marcela P. Henríquez1Cristian Salazar2Eric Rojas3Guadalupe Echeverría4Gayle D. Love5Attilio Rigotti6Christopher L. Coe7Carol D. Ryff8Department of Nutrition, Diabetes and Metabolism, Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de ChileELSA Clinical Laboratory, IntegraMedica, BupaDepartment of Nutrition, Diabetes and Metabolism, Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de ChileDepartment of Clinical Laboratory, School of Medicine, Pontificia Universidad Católica de ChileDepartment of Nutrition, Diabetes and Metabolism, Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de ChileInstitute on Aging, University of Wisconsin-MadisonDepartment of Nutrition, Diabetes and Metabolism, Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de ChileInstitute on Aging, University of Wisconsin-MadisonInstitute on Aging, University of Wisconsin-MadisonAbstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of middle-aged American adults (Midlife in the United States). Health behaviors (i.e., diet, exercise, and sleep) were also examined as potential mediators of these relationships. Serum levels of total ceramides—the main molecular class of sphingolipids previously associated with several disease conditions—were inversely linked with environmental mastery. In addition, significant correlations were found between specific ceramide, dihydroceramide, and hexosylceramides species with environmental mastery, purpose in life, and self-acceptance. Using hierarchical regression and mediation analyses, health behaviors appeared to mediate these associations. However, the link between ceramides and environmental mastery was partially independent of health behaviors, suggesting the role of additional mediating factors. These findings point to sphingolipid metabolism as a novel pathway of health benefits associated with psychological well-being. In particular, having a sense of environmental mastery may promote restorative behaviors and benefit health via improved blood sphingolipid profiles.https://doi.org/10.1038/s41598-021-92576-3 |
| spellingShingle | Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff Association between serum sphingolipids and eudaimonic well-being in white U.S. adults Scientific Reports |
| title | Association between serum sphingolipids and eudaimonic well-being in white U.S. adults |
| title_full | Association between serum sphingolipids and eudaimonic well-being in white U.S. adults |
| title_fullStr | Association between serum sphingolipids and eudaimonic well-being in white U.S. adults |
| title_full_unstemmed | Association between serum sphingolipids and eudaimonic well-being in white U.S. adults |
| title_short | Association between serum sphingolipids and eudaimonic well-being in white U.S. adults |
| title_sort | association between serum sphingolipids and eudaimonic well being in white u s adults |
| url | https://doi.org/10.1038/s41598-021-92576-3 |
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