Antagonism between FOXO and Myc regulates cellular powerhouse

Antagonism between FOXO and Myc regulates cellular powerhouse

Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis formation and tumour progression, thereby leading to a poorer clinical outcom...

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Bibliographic Details
Main Authors: Barrie ePeck, Emma Clare Ferber, Almut eSchulze
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
Metabolism
Mitochondria
Cancer
hypoxia
HIF
ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00096/full

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