Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study
Abstract Background Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. Methods This...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12877-017-0649-3 |
| _version_ | 1818972544395378688 |
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| author | Mingkai Peng Guanmin Chen Karen L. Tang Hude Quan Eric E. Smith Peter Faris Vladimir Hachinski Norm R. C. Campbell |
| author_facet | Mingkai Peng Guanmin Chen Karen L. Tang Hude Quan Eric E. Smith Peter Faris Vladimir Hachinski Norm R. C. Campbell |
| author_sort | Mingkai Peng |
| collection | DOAJ |
| description | Abstract Background Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. Methods This is a population-based observational study. 265,897 individuals with at least one BP measurement between the ages of 60 to 65 years and 211,116 individuals with at least one BP measurement between the ages of 70 to 75 years were extracted from The Health Improvement Network in United Kingdom. Blood pressures were categorized into four groups: normal, prehypertension, stage 1 hypertension, and stage 2 hypertension. Cases of VaD were identified from the recorded clinical diagnoses. Multivariable survival analysis was used to adjust other confounders and competing risk of death. All the analysis were stratified based on antihypertensive drug use status. Multiple imputation was used to fill in missing values. Results After accounting for the competing risk of death and adjustment for potential confounders, there was an association between higher BP levels in the age 60–65 cohort with the risk of developing VaD (hazard ratio [HR] 1.53 (95% confidence interval: 1.04, 2.25) for prehypertension, 1.90 (1.30, 2.78) for stage 1 hypertension, and 2.19 (1.48, 3.26) for stage 2 hypertension) in the untreated group. There was no statistically significant association between BP levels and VaD in the treated group in the age 60–65 cohort and age 70–75 cohort. Analysis on Pulse Pressure (PP) stratified by blood pressure level showed that PP was not independently associated with VaD. Conclusion High BP between the ages of 60 to 65 years is a significant risk for VaD in late midlife. Greater efforts should be placed on early diagnosis of hypertension and tight control of BP for hypertensive patients for the prevention of VaD. |
| first_indexed | 2024-12-20T15:09:57Z |
| format | Article |
| id | doaj.art-8ce0fa6ec4cd40299d9ae8c993b5d10f |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-20T15:09:57Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-8ce0fa6ec4cd40299d9ae8c993b5d10f2022-12-21T19:36:21ZengBMCBMC Geriatrics1471-23182017-10-0117111110.1186/s12877-017-0649-3Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational studyMingkai Peng0Guanmin Chen1Karen L. Tang2Hude Quan3Eric E. Smith4Peter Faris5Vladimir Hachinski6Norm R. C. Campbell7Department of Community Health Sciences, University of CalgaryAlberta Health ServicesCumming School of Medicine, University of CalgaryDepartment of Community Health Sciences, University of CalgaryDepartment of Clinical Neurosciences, University of CalgaryAlberta Health ServicesDepartment of Clinical Neurological Sciences, London Health Sciences Centre, Western UniversityDepartment of Medicine, Physiology and Pharmacology and Community Health Sciences, O’Brien Institute for Public Health and Libin Cardiovascular Institute of Alberta, University of CalgaryAbstract Background Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. Methods This is a population-based observational study. 265,897 individuals with at least one BP measurement between the ages of 60 to 65 years and 211,116 individuals with at least one BP measurement between the ages of 70 to 75 years were extracted from The Health Improvement Network in United Kingdom. Blood pressures were categorized into four groups: normal, prehypertension, stage 1 hypertension, and stage 2 hypertension. Cases of VaD were identified from the recorded clinical diagnoses. Multivariable survival analysis was used to adjust other confounders and competing risk of death. All the analysis were stratified based on antihypertensive drug use status. Multiple imputation was used to fill in missing values. Results After accounting for the competing risk of death and adjustment for potential confounders, there was an association between higher BP levels in the age 60–65 cohort with the risk of developing VaD (hazard ratio [HR] 1.53 (95% confidence interval: 1.04, 2.25) for prehypertension, 1.90 (1.30, 2.78) for stage 1 hypertension, and 2.19 (1.48, 3.26) for stage 2 hypertension) in the untreated group. There was no statistically significant association between BP levels and VaD in the treated group in the age 60–65 cohort and age 70–75 cohort. Analysis on Pulse Pressure (PP) stratified by blood pressure level showed that PP was not independently associated with VaD. Conclusion High BP between the ages of 60 to 65 years is a significant risk for VaD in late midlife. Greater efforts should be placed on early diagnosis of hypertension and tight control of BP for hypertensive patients for the prevention of VaD.http://link.springer.com/article/10.1186/s12877-017-0649-3Population based observational studyBlood pressureVascular dementiaPulse pressure |
| spellingShingle | Mingkai Peng Guanmin Chen Karen L. Tang Hude Quan Eric E. Smith Peter Faris Vladimir Hachinski Norm R. C. Campbell Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study BMC Geriatrics Population based observational study Blood pressure Vascular dementia Pulse pressure |
| title | Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study |
| title_full | Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study |
| title_fullStr | Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study |
| title_full_unstemmed | Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study |
| title_short | Blood pressure at age 60–65 versus age 70–75 and vascular dementia: a population based observational study |
| title_sort | blood pressure at age 60 65 versus age 70 75 and vascular dementia a population based observational study |
| topic | Population based observational study Blood pressure Vascular dementia Pulse pressure |
| url | http://link.springer.com/article/10.1186/s12877-017-0649-3 |
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