Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2015-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/74 |
| _version_ | 1797237418318888960 |
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| author | O. A. Ershova T. A. Bairova |
| author_facet | O. A. Ershova T. A. Bairova |
| author_sort | O. A. Ershova |
| collection | DOAJ |
| description | Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х2 = 14,250; р = 0,000) were found in the group of Buryat population. |
| first_indexed | 2024-03-08T12:20:06Z |
| format | Article |
| id | doaj.art-8ce51803dbb340f6bd63c317d90ea025 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:19:26Z |
| publishDate | 2015-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-8ce51803dbb340f6bd63c317d90ea0252024-03-28T07:49:14ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962015-05-0103707374Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern SiberiaO. A. Ershova0T. A. Bairova1Scientific Center for family Health and Human Reproduction ProblemsScientific Center for family Health and Human Reproduction ProblemsGenetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х2 = 14,250; р = 0,000) were found in the group of Buryat population.https://www.actabiomedica.ru/jour/article/view/74oxidative stressarterial hypertensionpolymorphismcatalaseethnos |
| spellingShingle | O. A. Ershova T. A. Bairova Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia Acta Biomedica Scientifica oxidative stress arterial hypertension polymorphism catalase ethnos |
| title | Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia |
| title_full | Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia |
| title_fullStr | Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia |
| title_full_unstemmed | Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia |
| title_short | Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia |
| title_sort | polymorphism 262c t of catalase gene rs1001179 in russian and buryat populations with essential hypertension living in the eastern siberia |
| topic | oxidative stress arterial hypertension polymorphism catalase ethnos |
| url | https://www.actabiomedica.ru/jour/article/view/74 |
| work_keys_str_mv | AT oaershova polymorphism262ctofcatalasegeners1001179inrussianandburyatpopulationswithessentialhypertensionlivingintheeasternsiberia AT tabairova polymorphism262ctofcatalasegeners1001179inrussianandburyatpopulationswithessentialhypertensionlivingintheeasternsiberia |