Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors
Abstract With CA16, enterovirus-71 is the causative agent of hand foot and mouth disease (HFMD) which occurs mostly in children under 5 years-old and responsible of several outbreaks since a decade. Most of the time, HFMD is a mild disease but can progress to severe complications such as meningitis,...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Virology Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12985-020-01430-x |
| _version_ | 1828957798173507584 |
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| author | Rominah Onintsoa Diarimalala Meichun Hu Yanhong Wei Kanghong Hu |
| author_facet | Rominah Onintsoa Diarimalala Meichun Hu Yanhong Wei Kanghong Hu |
| author_sort | Rominah Onintsoa Diarimalala |
| collection | DOAJ |
| description | Abstract With CA16, enterovirus-71 is the causative agent of hand foot and mouth disease (HFMD) which occurs mostly in children under 5 years-old and responsible of several outbreaks since a decade. Most of the time, HFMD is a mild disease but can progress to severe complications such as meningitis, brain stem encephalitis, acute flaccid paralysis (AFP) and even death; EV71 has been identified in all severe cases. Therefore, it is actually one of the most public health issues that threatens children’s life. $$3{\rm C}^{{\rm pro}}$$ 3 C pro is a protease which plays important functions in EV71 infection. To date, a lot of $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors have been tested but none of them has been approved yet. Therefore, a drug screening is still an utmost importance in order to treat and/or prevent EV71 infections. This work highlights the EV71 life cycle, $$3{\rm C}^{{\rm pro}}$$ 3 C pro functions and $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors recently screened. It permits to well understand all mechanisms about $$3{\rm C}^{{\rm pro}}$$ 3 C pro and consequently allow further development of drugs targeting $$3{\rm C}^{{\rm pro}}$$ 3 C pro . Thus, this review is helpful for screening of more new $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors or for designing analogues of well known $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors in order to improve its antiviral activity. |
| first_indexed | 2024-12-14T08:36:40Z |
| format | Article |
| id | doaj.art-8ce7df1954fb43b295e57f372cc81bbf |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T08:36:40Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-8ce7df1954fb43b295e57f372cc81bbf2022-12-21T23:09:24ZengBMCVirology Journal1743-422X2020-11-011711910.1186/s12985-020-01430-xRecent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting InhibitorsRominah Onintsoa Diarimalala0Meichun Hu1Yanhong Wei2Kanghong Hu3National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of TechnologyNational 111 Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of TechnologyNational 111 Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of TechnologyNational 111 Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of TechnologyAbstract With CA16, enterovirus-71 is the causative agent of hand foot and mouth disease (HFMD) which occurs mostly in children under 5 years-old and responsible of several outbreaks since a decade. Most of the time, HFMD is a mild disease but can progress to severe complications such as meningitis, brain stem encephalitis, acute flaccid paralysis (AFP) and even death; EV71 has been identified in all severe cases. Therefore, it is actually one of the most public health issues that threatens children’s life. $$3{\rm C}^{{\rm pro}}$$ 3 C pro is a protease which plays important functions in EV71 infection. To date, a lot of $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors have been tested but none of them has been approved yet. Therefore, a drug screening is still an utmost importance in order to treat and/or prevent EV71 infections. This work highlights the EV71 life cycle, $$3{\rm C}^{{\rm pro}}$$ 3 C pro functions and $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors recently screened. It permits to well understand all mechanisms about $$3{\rm C}^{{\rm pro}}$$ 3 C pro and consequently allow further development of drugs targeting $$3{\rm C}^{{\rm pro}}$$ 3 C pro . Thus, this review is helpful for screening of more new $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors or for designing analogues of well known $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors in order to improve its antiviral activity.http://link.springer.com/article/10.1186/s12985-020-01430-xEnterovirus 71Enterovirus 71 life cycle$$3{\rm C}^{{\rm pro}}$$ 3 C pro functions$$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitorsEV71 drugs screening |
| spellingShingle | Rominah Onintsoa Diarimalala Meichun Hu Yanhong Wei Kanghong Hu Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors Virology Journal Enterovirus 71 Enterovirus 71 life cycle $$3{\rm C}^{{\rm pro}}$$ 3 C pro functions $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors EV71 drugs screening |
| title | Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors |
| title_full | Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors |
| title_fullStr | Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors |
| title_full_unstemmed | Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors |
| title_short | Recent advances of enterovirus 71 $$3{\rm C}^{{\rm pro}}$$ 3 C pro targeting Inhibitors |
| title_sort | recent advances of enterovirus 71 3 rm c rm pro 3 c pro targeting inhibitors |
| topic | Enterovirus 71 Enterovirus 71 life cycle $$3{\rm C}^{{\rm pro}}$$ 3 C pro functions $$3{\rm C}^{{\rm pro}}$$ 3 C pro inhibitors EV71 drugs screening |
| url | http://link.springer.com/article/10.1186/s12985-020-01430-x |
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