Impaired immunosuppressive effect of bone marrow mesenchymal stem cell-derived exosomes on T cells in aplastic anemia

Impaired immunosuppressive effect of bone marrow mesenchymal stem cell-derived exosomes on T cells in aplastic anemia

Abstract Background Previous studies have verified the dysfunction of mesenchymal stem cells (MSCs) for immunoregulation in acquired aplastic anemia (AA) patients. Exosomes derived from MSCs can partially substitute MSCs acting as immune regulator. Dysfunction of exosomes (Exos) derived from AA-MSC...

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Bibliographic Details
Main Authors: Shichong Wang, Jiali Huo, Yilin Liu, Lingyun Chen, Xiang Ren, Xingxin Li, Min Wang, Peng Jin, Jinbo Huang, Neng Nie, Jing Zhang, Yingqi Shao, Meili Ge, Yizhou Zheng
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Stem Cell Research & Therapy
Subjects:
Acquired aplastic anemia
Exosome
microRNA
Immunoregulation
Online Access:https://doi.org/10.1186/s13287-023-03496-0

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