The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study
Abstract Aim The aim of this retrospective study was to investigate the incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer. Methods This study involved 2017 patients with stages 0‐III colorectal cancer who underwent laparoscopic surgery at 17 Japan...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12531 |
| _version_ | 1811255739202666496 |
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| author | Nobuki Ichikawa Shigenori Homma Tohru Funakoshi Keisuke Obuchi Takahiro Ohshima Kazuhito Uemura Hirofumi Kon Yosuke Ohno Ryoichi Yokota Akinobu Taketomi Hokkaido Colorectal Surgical Research Group Collaborative |
| author_facet | Nobuki Ichikawa Shigenori Homma Tohru Funakoshi Keisuke Obuchi Takahiro Ohshima Kazuhito Uemura Hirofumi Kon Yosuke Ohno Ryoichi Yokota Akinobu Taketomi Hokkaido Colorectal Surgical Research Group Collaborative |
| author_sort | Nobuki Ichikawa |
| collection | DOAJ |
| description | Abstract Aim The aim of this retrospective study was to investigate the incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer. Methods This study involved 2017 patients with stages 0‐III colorectal cancer who underwent laparoscopic surgery at 17 Japanese hospitals between January 2010 and December 2013. We assessed the incidence of postoperative cardiovascular thrombotic and haemorrhagic complications. Results Laparoscopic surgeries were performed in 1152 men and 865 women with 1405 colon and 612 rectal cancers, respectively. Overall, 3%, 38%, 17%, 8%, and 9% of patients had comorbidities of heart failure, high blood pressure, diabetes, history of stroke, and vascular disease, respectively. Antithrombotic agents were being consumed by 17% of patients. The types (and perioperative rest periods) of the antithrombotic agents were aspirin in 58% (18.6 days), clopidogrel in 19% (21.1 days), cilostazol in 13% (13.3 days), and warfarin potassium in 21% (14.6 days) of cases with antithrombotic agents. Surgical time and blood loss in the total cohort were 234 minutes and 56 mL. Four cases (0.2%) had cardiovascular thrombotic complications, including one severe cardiac infarction and one stroke with major sequelae (CHADS2 scores were 2 points in both cases). Hemorrhagic complications occurred in 19 cases (0.9%). In particular, the incidence of the major gastroduodenal haemorrhagic ulcer was higher in cases with antithrombotic agents than without them (0.05% vs 0%, P = .02). Conclusion The incidence of cardiovascular thrombotic complications was rare, although severe cardiac infarction and stroke could occur even after minimally invasive surgery in colorectal cancer. |
| first_indexed | 2024-04-12T17:29:18Z |
| format | Article |
| id | doaj.art-8ce9f6ecf6534d92a62f9c1d29ae05a1 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-12T17:29:18Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-8ce9f6ecf6534d92a62f9c1d29ae05a12022-12-22T03:23:11ZengWileyAnnals of Gastroenterological Surgery2475-03282022-05-016339640410.1002/ags3.12531The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical studyNobuki Ichikawa0Shigenori Homma1Tohru Funakoshi2Keisuke Obuchi3Takahiro Ohshima4Kazuhito Uemura5Hirofumi Kon6Yosuke Ohno7Ryoichi Yokota8Akinobu Taketomi9Hokkaido Colorectal Surgical Research Group CollaborativeDepartment of Gastroenterological Surgery I Graduate School of Medicine Hokkaido University Sapporo JapanDepartment of Gastroenterological Surgery I Graduate School of Medicine Hokkaido University Sapporo JapanDepartment of Surgery Sapporo‐Kosei General Hospital Sapporo JapanDepartment of Surgery Hakodate Municipal Hospital Hakodate JapanDepartment of Surgery Sapporo City General Hospital Sapporo JapanDepartment of Surgery Tomakomai City Hospital Tomakomai JapanDepartment of Surgery KKR Sapporo Medical Center Sapporo JapanDepartment of Surgery Asahikawa‐Kosei General Hospital Asahikawa JapanDepartment of Surgery Sunagawa City Medical Center Sunagawa JapanDepartment of Gastroenterological Surgery I Graduate School of Medicine Hokkaido University Sapporo JapanAbstract Aim The aim of this retrospective study was to investigate the incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer. Methods This study involved 2017 patients with stages 0‐III colorectal cancer who underwent laparoscopic surgery at 17 Japanese hospitals between January 2010 and December 2013. We assessed the incidence of postoperative cardiovascular thrombotic and haemorrhagic complications. Results Laparoscopic surgeries were performed in 1152 men and 865 women with 1405 colon and 612 rectal cancers, respectively. Overall, 3%, 38%, 17%, 8%, and 9% of patients had comorbidities of heart failure, high blood pressure, diabetes, history of stroke, and vascular disease, respectively. Antithrombotic agents were being consumed by 17% of patients. The types (and perioperative rest periods) of the antithrombotic agents were aspirin in 58% (18.6 days), clopidogrel in 19% (21.1 days), cilostazol in 13% (13.3 days), and warfarin potassium in 21% (14.6 days) of cases with antithrombotic agents. Surgical time and blood loss in the total cohort were 234 minutes and 56 mL. Four cases (0.2%) had cardiovascular thrombotic complications, including one severe cardiac infarction and one stroke with major sequelae (CHADS2 scores were 2 points in both cases). Hemorrhagic complications occurred in 19 cases (0.9%). In particular, the incidence of the major gastroduodenal haemorrhagic ulcer was higher in cases with antithrombotic agents than without them (0.05% vs 0%, P = .02). Conclusion The incidence of cardiovascular thrombotic complications was rare, although severe cardiac infarction and stroke could occur even after minimally invasive surgery in colorectal cancer.https://doi.org/10.1002/ags3.12531colorectal neoplasmsischemic heart diseaselaparoscopystrokethrombosis |
| spellingShingle | Nobuki Ichikawa Shigenori Homma Tohru Funakoshi Keisuke Obuchi Takahiro Ohshima Kazuhito Uemura Hirofumi Kon Yosuke Ohno Ryoichi Yokota Akinobu Taketomi Hokkaido Colorectal Surgical Research Group Collaborative The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study Annals of Gastroenterological Surgery colorectal neoplasms ischemic heart disease laparoscopy stroke thrombosis |
| title | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study |
| title_full | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study |
| title_fullStr | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study |
| title_full_unstemmed | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study |
| title_short | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large‐scale clinical study |
| title_sort | incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in japanese hospitals a large scale clinical study |
| topic | colorectal neoplasms ischemic heart disease laparoscopy stroke thrombosis |
| url | https://doi.org/10.1002/ags3.12531 |
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