Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers
Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00077/full |
| _version_ | 1819180217066848256 |
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| author | Joo-In ePark Hae-Rahn eBae Chang Gun eKim Valentin A. Stonik Jong-Young eKwak |
| author_facet | Joo-In ePark Hae-Rahn eBae Chang Gun eKim Valentin A. Stonik Jong-Young eKwak |
| author_sort | Joo-In ePark |
| collection | DOAJ |
| description | Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms. |
| first_indexed | 2024-12-22T22:10:49Z |
| format | Article |
| id | doaj.art-8cea63b765124320bd5675b6b7432865 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-22T22:10:49Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-8cea63b765124320bd5675b6b74328652022-12-21T18:10:53ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462014-09-01210.3389/fchem.2014.00077107829Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbersJoo-In ePark0Hae-Rahn eBae1Chang Gun eKim2Valentin A. Stonik3Jong-Young eKwak4Dong-A universityDong-A universityDong-A universityG.B.Elyakov Pacific Institute of Bioorganic ChemistryDong-A universityMany marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms.http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00077/fullAnticancer activitymembrane transporterstriterpene glycosidesFrondoside ACucumariosideStichoposides |
| spellingShingle | Joo-In ePark Hae-Rahn eBae Chang Gun eKim Valentin A. Stonik Jong-Young eKwak Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers Frontiers in Chemistry Anticancer activity membrane transporters triterpene glycosides Frondoside A Cucumarioside Stichoposides |
| title | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| title_full | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| title_fullStr | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| title_full_unstemmed | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| title_short | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| title_sort | relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
| topic | Anticancer activity membrane transporters triterpene glycosides Frondoside A Cucumarioside Stichoposides |
| url | http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00077/full |
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