Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway

Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway

The aim of the present research was to investigate the effects of irisin, a skeletal muscle-derived myokine, on spinal cord injury (SCI) in rats and explore the possible mechanisms. SCI model was constructed in male SD rats. The effects of irisin on SCI rats were assessed via behavior tests includin...

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Bibliographic Details
Main Authors: Xi Jiang, Zhihong Shen, Jin Chen, Chao Wang, Zhan Gao, Songling Yu, Xuefeng Yu, Lei Chen, Lexing Xu, Ziwei Chen, Wenjuan Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
irisin
spinal cord injury
motor function
lipopolysaccharide
adenosine 5'-monophosphate (AMP)-activated protein kinase
nuclear factor kappa-B
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.582484/full

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