Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report

The novel coronavirus disease (COVID-19) quickly spread to all continents. However, data regarding all the signs and symptoms of COVID-19 are insufficient. Patients with COVID-19 might present higher susceptibility to fungal coinfections. Mucormycosis is a rare and often life-threatening fungal dise...

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Main Authors: Epifanio Silvino do Monte Junior, Marcos Eduardo Lera dos Santos, Igor Braga Ribeiro, Gustavo de Oliveira Luz, Elisa Ryoka Baba, Bruno Salomão Hirsch, Mateus Pereira Funari, Eduardo Guimarães Hourneaux de Moura
Format: Article
Language:English
Published: Korean Society of Gastrointestinal Endoscopy 2020-11-01
Series:Clinical Endoscopy
Subjects:
Online Access:http://www.e-ce.org/upload/pdf/ce-2020-180.pdf
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author Epifanio Silvino do Monte Junior
Marcos Eduardo Lera dos Santos
Igor Braga Ribeiro
Gustavo de Oliveira Luz
Elisa Ryoka Baba
Bruno Salomão Hirsch
Mateus Pereira Funari
Eduardo Guimarães Hourneaux de Moura
author_facet Epifanio Silvino do Monte Junior
Marcos Eduardo Lera dos Santos
Igor Braga Ribeiro
Gustavo de Oliveira Luz
Elisa Ryoka Baba
Bruno Salomão Hirsch
Mateus Pereira Funari
Eduardo Guimarães Hourneaux de Moura
author_sort Epifanio Silvino do Monte Junior
collection DOAJ
description The novel coronavirus disease (COVID-19) quickly spread to all continents. However, data regarding all the signs and symptoms of COVID-19 are insufficient. Patients with COVID-19 might present higher susceptibility to fungal coinfections. Mucormycosis is a rare and often life-threatening fungal disease characterized by vascular invasion by hyphae, resulting in thrombosis and necrosis. This is the first case report of mucormycosis in a COVID-19 patient. An 86-year-old male patient was admitted to the emergency room with acute diarrhea, cough, dyspnea, and fever from 5 days prior. Blood tests revealed a hemoglobin level of 14.3 mg/dL. Five days following the admission, the patient presented with melena and a hemoglobin level of 5.6 mg/dL. A transfusion of three units of red blood cells was required. Esophagogastroduodenoscopy revealed two giant gastric ulcers with necrotic debris and a deep hemorrhagic base without active bleeding. Furthermore, biopsies confirmed mucormycosis. Despite intensive care, the patient died 36 hours after the esophagogastroduodenoscopy.
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spelling doaj.art-8cec9e2ba9364807bb9bf11528d506b42023-12-03T03:32:23ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432020-11-0153674674910.5946/ce.2020.1807430Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case ReportEpifanio Silvino do Monte Junior0Marcos Eduardo Lera dos Santos1Igor Braga Ribeiro2Gustavo de Oliveira Luz3Elisa Ryoka Baba4Bruno Salomão Hirsch5Mateus Pereira Funari6Eduardo Guimarães Hourneaux de Moura7 Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrasilThe novel coronavirus disease (COVID-19) quickly spread to all continents. However, data regarding all the signs and symptoms of COVID-19 are insufficient. Patients with COVID-19 might present higher susceptibility to fungal coinfections. Mucormycosis is a rare and often life-threatening fungal disease characterized by vascular invasion by hyphae, resulting in thrombosis and necrosis. This is the first case report of mucormycosis in a COVID-19 patient. An 86-year-old male patient was admitted to the emergency room with acute diarrhea, cough, dyspnea, and fever from 5 days prior. Blood tests revealed a hemoglobin level of 14.3 mg/dL. Five days following the admission, the patient presented with melena and a hemoglobin level of 5.6 mg/dL. A transfusion of three units of red blood cells was required. Esophagogastroduodenoscopy revealed two giant gastric ulcers with necrotic debris and a deep hemorrhagic base without active bleeding. Furthermore, biopsies confirmed mucormycosis. Despite intensive care, the patient died 36 hours after the esophagogastroduodenoscopy.http://www.e-ce.org/upload/pdf/ce-2020-180.pdfcoronavirus infectionsgastroenteritisgastrointestinal hemorrhagemucormycosiszygomycosis
spellingShingle Epifanio Silvino do Monte Junior
Marcos Eduardo Lera dos Santos
Igor Braga Ribeiro
Gustavo de Oliveira Luz
Elisa Ryoka Baba
Bruno Salomão Hirsch
Mateus Pereira Funari
Eduardo Guimarães Hourneaux de Moura
Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
Clinical Endoscopy
coronavirus infections
gastroenteritis
gastrointestinal hemorrhage
mucormycosis
zygomycosis
title Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
title_full Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
title_fullStr Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
title_full_unstemmed Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
title_short Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
title_sort rare and fatal gastrointestinal mucormycosis zygomycosis in a covid 19 patient a case report
topic coronavirus infections
gastroenteritis
gastrointestinal hemorrhage
mucormycosis
zygomycosis
url http://www.e-ce.org/upload/pdf/ce-2020-180.pdf
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