Caffeic acid ethanolamide induces antifibrosis, anti-inflammatory, and antioxidant effects protects against bleomycin-induced pulmonary fibrosis

Caffeic acid ethanolamide induces antifibrosis, anti-inflammatory, and antioxidant effects protects against bleomycin-induced pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease; its cause is unknown, and it leads to notable health problems. Currently, only two drugs are recommended for IPF treatment. Although these drugs can mitigate lung function decline, neither can improve nor sta...

Full description

Bibliographic Details
Main Authors:	Cheng-Wei Huang, Shih-Yi Lee, Chen-Xuan Du, Shao-Tung Wu, Yueh-Hsiung Kuo, Hui-Chun Ku
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Fibroblast Myofibroblast Pulmonary fibrosis TGF-β SMAD
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332224001793

Similar Items

A novel caffeic acid derivative prevents angiotensin II-induced cardiac remodeling
by: Shih-Yi Lee, et al.
Published: (2023-06-01)

Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
by: Peng Liu, et al.
Published: (2020-02-01)

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway
by: Jintao Jiang, et al.
Published: (2020-05-01)

Antifibrotic Mechanism of Piceatannol in Bleomycin-Induced Pulmonary Fibrosis in Mice
by: Hanjing Sheng, et al.
Published: (2022-06-01)

Antifibrotic mechanism of avitinib in bleomycin-induced pulmonary fibrosis in mice
by: Yang Miao, et al.
Published: (2023-03-01)

Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression
by: Yuan Ji-hong, et al.
Published: (2023-12-01)

Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway
by: Xiaohe Li, et al.
Published: (2021-02-01)

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro
by: Zun-En Xia, et al.
Published: (2018-10-01)

The Yin and Yang of Mesenchymal Cells in the Corneal Stromal Fibrosis Response to Injury: The Cornea as a Model of Fibrosis in Other Organs
by: Steven E. Wilson
Published: (2022-12-01)

Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation
by: Sofia Libório-Ramos, et al.
Published: (2023-01-01)

Atractylodin ameliorates bleomycin-induced pulmonary inflammation and fibrosis in mice
by: Zhenhui Wu, et al.
Published: (2023-09-01)

Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats
by: Yu-Ling Duan, et al.
Published: (2023-01-01)

Fibrosis Is a Basement Membrane-Related Disease in the Cornea: Injury and Defective Regeneration of Basement Membranes May Underlie Fibrosis in Other Organs
by: Steven E. Wilson
Published: (2022-01-01)

Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Perspective from Fibroblasts
by: Maja Schlittler, et al.
Published: (2023-10-01)

Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling
by: Eleanor B. Reed, et al.
Published: (2019-07-01)

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model
by: Xichun Qin, et al.
Published: (2022-04-01)

Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis
by: Yusuke Higuchi, et al.
Published: (2024-02-01)

The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats
by: Ku Chang-Wen, et al.
Published: (2021-11-01)

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition
by: Xiao-Ming Zhou, et al.
Published: (2017-12-01)

CVD and COVID-19: Emerging Roles of Cardiac Fibroblasts and Myofibroblasts
by: Laxmansa C. Katwa, et al.
Published: (2022-04-01)

Design and Synthesis of Matrine Derivatives as Novel Anti-Pulmonary Fibrotic Agents via Repression of the TGFβ/Smad Pathway
by: Lingyu Li, et al.
Published: (2019-03-01)

Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis
by: Beomgu Lee, et al.
Published: (2024-12-01)

Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II/Transformation Growth Factor β1 Fibrogenic Axis
by: Xiao Liu, et al.
Published: (2019-05-01)

Derrone Targeting the TGF Type 1 Receptor Kinase Improves Bleomycin-Mediated Pulmonary Fibrosis through Inhibition of Smad Signaling Pathway
by: Ilandarage Menu Neelaka Molagoda, et al.
Published: (2023-04-01)

Mechanical and Physical Regulation of Fibroblast–Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology
by: Mirko D'Urso, et al.
Published: (2020-12-01)

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation
by: Jing Cheng, et al.
Published: (2022-10-01)

Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation
by: Jie Dong, et al.
Published: (2017-06-01)

TRPV4 Mechanotransduction in Fibrosis
by: Ravi K. Adapala, et al.
Published: (2021-11-01)

Role of endothelin in lung fibrosis
by: D. Abraham
Published: (2008-12-01)

Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-β1 Signaling Pathway
by: Hao Ruan, et al.
Published: (2021-07-01)

Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats
by: Mushuang Qi, et al.
Published: (2024-12-01)

Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice
by: Yuanyuan Han, et al.
Published: (2021-09-01)

Elucidating the cellular mechanism for E2-induced dermal fibrosis
by: DeAnna Baker Frost, et al.
Published: (2021-02-01)

Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis
by: Amir Larki-Harchegani, et al.
Published: (2013-07-01)

Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling
by: Ying Wang, et al.
Published: (2022-05-01)

Fibroblasts in fibrosis: novel roles and mediators
by: Ryan Thomas Kendall, et al.
Published: (2014-05-01)

Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial–Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo
by: Tianxiao Sun, et al.
Published: (2023-03-01)

Ellagic Acid Inhibits TGFβ1/Smad-Induced Renal Fibrosis in Diabetic Kidney Injury
by: Ozkan Gorgulu, et al.
Published: (2022-12-01)

SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma
by: Milena Paw, et al.
Published: (2021-11-01)

Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge
by: Bram ePiersma, et al.
Published: (2015-09-01)