Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process
Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 °C, precipita...
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| Format: | Article |
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MDPI AG
2016-12-01
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| Series: | Applied Sciences |
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| Online Access: | http://www.mdpi.com/2076-3417/7/1/10 |
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| author | Xiaonan Zhang Xia Wu Fengying Xie Zhongjiang Wang Xiuling Zhang Lianzhou Jiang |
| author_facet | Xiaonan Zhang Xia Wu Fengying Xie Zhongjiang Wang Xiuling Zhang Lianzhou Jiang |
| author_sort | Xiaonan Zhang |
| collection | DOAJ |
| description | Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 °C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent into the antisolvent of 44 mL/h, antisolvent (water) to solvent (dimethyl sulfide (DMSO)) volume ratio of 7:1, and shear rate of 5000 rpm. With this HAP process, the mean particle size was 228.36 ± 3.99 nm. The micronized spiramycin was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, high-performance liquid chromatography, and gas chromatograph analyses. In comparison with the raw drug, the chemical structure of micronized spiramycin was not changed. The dissolution rate experiments showed that the dissolution rate of the spiramycin was significantly increased after micronization. |
| first_indexed | 2024-04-12T21:23:46Z |
| format | Article |
| id | doaj.art-8cedc16e9a564f6db08eab6766436bbd |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-12T21:23:46Z |
| publishDate | 2016-12-01 |
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| series | Applied Sciences |
| spelling | doaj.art-8cedc16e9a564f6db08eab6766436bbd2022-12-22T03:16:13ZengMDPI AGApplied Sciences2076-34172016-12-01711010.3390/app7010010app7010010Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation ProcessXiaonan Zhang0Xia Wu1Fengying Xie2Zhongjiang Wang3Xiuling Zhang4Lianzhou Jiang5Key Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, ChinaDue to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 °C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent into the antisolvent of 44 mL/h, antisolvent (water) to solvent (dimethyl sulfide (DMSO)) volume ratio of 7:1, and shear rate of 5000 rpm. With this HAP process, the mean particle size was 228.36 ± 3.99 nm. The micronized spiramycin was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, high-performance liquid chromatography, and gas chromatograph analyses. In comparison with the raw drug, the chemical structure of micronized spiramycin was not changed. The dissolution rate experiments showed that the dissolution rate of the spiramycin was significantly increased after micronization.http://www.mdpi.com/2076-3417/7/1/10spiramycinmicronizationhomogenate-antisolvent precipitationdissolution rate |
| spellingShingle | Xiaonan Zhang Xia Wu Fengying Xie Zhongjiang Wang Xiuling Zhang Lianzhou Jiang Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process Applied Sciences spiramycin micronization homogenate-antisolvent precipitation dissolution rate |
| title | Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process |
| title_full | Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process |
| title_fullStr | Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process |
| title_full_unstemmed | Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process |
| title_short | Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process |
| title_sort | physicochemical properties and in vitro dissolution of spiramycin microparticles using the homogenate antisolvent precipitation process |
| topic | spiramycin micronization homogenate-antisolvent precipitation dissolution rate |
| url | http://www.mdpi.com/2076-3417/7/1/10 |
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