Recent and Ongoing Research into Metastatic Osteosarcoma Treatments
The survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery. Over two thirds of metastatic osteosarcoma patients, many of whom are children or adolescents, fail to exhibit durable resp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/7/3817 |
| _version_ | 1797439008638238720 |
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| author | Michael A. Harris Christine J. Hawkins |
| author_facet | Michael A. Harris Christine J. Hawkins |
| author_sort | Michael A. Harris |
| collection | DOAJ |
| description | The survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery. Over two thirds of metastatic osteosarcoma patients, many of whom are children or adolescents, fail to exhibit durable responses and succumb to their disease. Concerted efforts have been made to increase survival rates through identification of candidate therapies via animal studies and early phase trials of novel treatments, but unfortunately, this work has produced negligible improvements to the survival rate for metastatic osteosarcoma patients. This review summarizes data from clinical trials of metastatic osteosarcoma therapies as well as pre-clinical studies that report efficacy of novel drugs against metastatic osteosarcoma in vivo. Considerations regarding the design of animal studies and clinical trials to improve survival outcomes for metastatic osteosarcoma patients are also discussed. |
| first_indexed | 2024-03-09T11:45:36Z |
| format | Article |
| id | doaj.art-8ceddfd0391f4e0b852c6fed68e2bc4d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:45:36Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8ceddfd0391f4e0b852c6fed68e2bc4d2023-11-30T23:22:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237381710.3390/ijms23073817Recent and Ongoing Research into Metastatic Osteosarcoma TreatmentsMichael A. Harris0Christine J. Hawkins1Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, AustraliaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, AustraliaThe survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery. Over two thirds of metastatic osteosarcoma patients, many of whom are children or adolescents, fail to exhibit durable responses and succumb to their disease. Concerted efforts have been made to increase survival rates through identification of candidate therapies via animal studies and early phase trials of novel treatments, but unfortunately, this work has produced negligible improvements to the survival rate for metastatic osteosarcoma patients. This review summarizes data from clinical trials of metastatic osteosarcoma therapies as well as pre-clinical studies that report efficacy of novel drugs against metastatic osteosarcoma in vivo. Considerations regarding the design of animal studies and clinical trials to improve survival outcomes for metastatic osteosarcoma patients are also discussed.https://www.mdpi.com/1422-0067/23/7/3817osteosarcomametastasismetastasessarcomatyrosine kinase inhibitorsimmunotherapy |
| spellingShingle | Michael A. Harris Christine J. Hawkins Recent and Ongoing Research into Metastatic Osteosarcoma Treatments International Journal of Molecular Sciences osteosarcoma metastasis metastases sarcoma tyrosine kinase inhibitors immunotherapy |
| title | Recent and Ongoing Research into Metastatic Osteosarcoma Treatments |
| title_full | Recent and Ongoing Research into Metastatic Osteosarcoma Treatments |
| title_fullStr | Recent and Ongoing Research into Metastatic Osteosarcoma Treatments |
| title_full_unstemmed | Recent and Ongoing Research into Metastatic Osteosarcoma Treatments |
| title_short | Recent and Ongoing Research into Metastatic Osteosarcoma Treatments |
| title_sort | recent and ongoing research into metastatic osteosarcoma treatments |
| topic | osteosarcoma metastasis metastases sarcoma tyrosine kinase inhibitors immunotherapy |
| url | https://www.mdpi.com/1422-0067/23/7/3817 |
| work_keys_str_mv | AT michaelaharris recentandongoingresearchintometastaticosteosarcomatreatments AT christinejhawkins recentandongoingresearchintometastaticosteosarcomatreatments |