Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits
Non-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic liver disease among all ages and ethnicities. Metabolic disorders, such as obesity and insulin resistance, are closely associated with sarcopenia and NAFLD. Sarcopenic obesity is a clinical di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/2/119 |
| _version_ | 1797414873632604160 |
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| author | Saad Emhmed Ali Mindie H. Nguyen |
| author_facet | Saad Emhmed Ali Mindie H. Nguyen |
| author_sort | Saad Emhmed Ali |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic liver disease among all ages and ethnicities. Metabolic disorders, such as obesity and insulin resistance, are closely associated with sarcopenia and NAFLD. Sarcopenic obesity is a clinical disorder characterized by the simultaneous loss of skeletal muscle and gain of adipose tissue. It is associated with worse outcomes in individuals with NAFLD. It is projected that NAFLD and sarcopenia will rise as the prevalence of obesity continues to increase at an unparallel rate. Recently, sarcopenia and sarcopenic obesity have gained considerable interest, but we still lack a well-defined definition and a management approach. Therefore, it is imperative to continue shining the light on this topic and better understand the underlying mechanism as well as treatment options. In this review article, we aimed to address the pathophysiology, impact, and outcomes of sarcopenic obesity on NAFLD. |
| first_indexed | 2024-03-09T05:40:20Z |
| format | Article |
| id | doaj.art-8cef5022ebf944689908b66514646d1e |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T05:40:20Z |
| publishDate | 2021-02-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-8cef5022ebf944689908b66514646d1e2023-12-03T12:25:55ZengMDPI AGLife2075-17292021-02-0111211910.3390/life11020119Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two CulpritsSaad Emhmed Ali0Mindie H. Nguyen1Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA 94304, USADepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA 94304, USANon-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic liver disease among all ages and ethnicities. Metabolic disorders, such as obesity and insulin resistance, are closely associated with sarcopenia and NAFLD. Sarcopenic obesity is a clinical disorder characterized by the simultaneous loss of skeletal muscle and gain of adipose tissue. It is associated with worse outcomes in individuals with NAFLD. It is projected that NAFLD and sarcopenia will rise as the prevalence of obesity continues to increase at an unparallel rate. Recently, sarcopenia and sarcopenic obesity have gained considerable interest, but we still lack a well-defined definition and a management approach. Therefore, it is imperative to continue shining the light on this topic and better understand the underlying mechanism as well as treatment options. In this review article, we aimed to address the pathophysiology, impact, and outcomes of sarcopenic obesity on NAFLD.https://www.mdpi.com/2075-1729/11/2/119sarcopenianon-alcoholic fatty liver diseaseobesityinsulin resistanceprevalencemetabolic diseases |
| spellingShingle | Saad Emhmed Ali Mindie H. Nguyen Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits Life sarcopenia non-alcoholic fatty liver disease obesity insulin resistance prevalence metabolic diseases |
| title | Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits |
| title_full | Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits |
| title_fullStr | Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits |
| title_full_unstemmed | Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits |
| title_short | Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits |
| title_sort | sarcopenic obesity in non alcoholic fatty liver disease the union of two culprits |
| topic | sarcopenia non-alcoholic fatty liver disease obesity insulin resistance prevalence metabolic diseases |
| url | https://www.mdpi.com/2075-1729/11/2/119 |
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