Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways

Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways

Sepsis and septic shock are the leading causes of death among hospitalized patients in the US. The immune response in sepsis transitions from a pro-inflammatory and pro-oxidant hyper-inflammation to an anti-inflammatory and cytoprotective hypo-inflammatory phase. While 1/3rd sepsis-related deaths oc...

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Bibliographic Details
Main Authors: Anugraha Gandhirajan, Sanjoy Roychowdhury, Vidula Vachharajani
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
sepsis
immune response
oxidative stress
mitochondrial dysfunction
epigenetic programming
sirtuins
Online Access:https://www.mdpi.com/2076-3921/11/1/3

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