Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome
Bone-derived osteocalcin has been suggested to be a metabolic regulator. To scrutinize the relation between osteocalcin and peripheral insulin sensitivity, we analyzed changes in serum osteocalcin relative to changes in insulin sensitivity, low-grade inflammation, and bone mineral density following...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2218-1989/11/8/526 |
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| author | Silke Zimmermann Maria Beatriz Walter Costa Akash Mathew Shruthi Krishnan Jochen G. Schneider Kirsten Roomp Berend Isermann Ronald Biemann |
| author_facet | Silke Zimmermann Maria Beatriz Walter Costa Akash Mathew Shruthi Krishnan Jochen G. Schneider Kirsten Roomp Berend Isermann Ronald Biemann |
| author_sort | Silke Zimmermann |
| collection | DOAJ |
| description | Bone-derived osteocalcin has been suggested to be a metabolic regulator. To scrutinize the relation between osteocalcin and peripheral insulin sensitivity, we analyzed changes in serum osteocalcin relative to changes in insulin sensitivity, low-grade inflammation, and bone mineral density following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). Participants with MetS were randomized to a weight loss program or to a control group. Before and after the 6-month intervention period, clinical and laboratory parameters and serum osteocalcin levels were determined. Changes in body composition were analyzed by dual-energy X-ray absorptiometry (DXA). In participants of the intervention group, weight loss resulted in improved insulin sensitivity and amelioration of inflammation. Increased serum levels of osteocalcin correlated inversely with BMI (r = −0.63; <i>p</i><i><</i> 0.001), total fat mass (r = −0.58, <i>p</i> < 0.001), total lean mass (r = −0.45, <i>p</i> < 0.001), C-reactive protein (CRP) (r = −0.37; <i>p</i> < 0.01), insulin (r = −0.4; <i>p</i> < 0.001), leptin (r = −0.53; <i>p</i> < 0.001), triglycerides (r = −0.42; <i>p</i> < 0.001), and alanine aminotransferase (ALAT) (r = −0.52; <i>p</i> < 0.001). Regression analysis revealed that osteocalcin was independently associated with changes in CRP but not with changes in insulin concentration, fat mass, or bone mineral density, suggesting that weight loss-induced higher serum osteocalcin is primarily associated with reduced inflammation. |
| first_indexed | 2024-03-10T08:36:18Z |
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| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:36:18Z |
| publishDate | 2021-08-01 |
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| series | Metabolites |
| spelling | doaj.art-8cf57a6b283744429a12f645beb64e282023-11-22T08:39:35ZengMDPI AGMetabolites2218-19892021-08-0111852610.3390/metabo11080526Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic SyndromeSilke Zimmermann0Maria Beatriz Walter Costa1Akash Mathew2Shruthi Krishnan3Jochen G. Schneider4Kirsten Roomp5Berend Isermann6Ronald Biemann7Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, 4362 Luxembourg, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, 4362 Luxembourg, LuxembourgInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, GermanyBone-derived osteocalcin has been suggested to be a metabolic regulator. To scrutinize the relation between osteocalcin and peripheral insulin sensitivity, we analyzed changes in serum osteocalcin relative to changes in insulin sensitivity, low-grade inflammation, and bone mineral density following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). Participants with MetS were randomized to a weight loss program or to a control group. Before and after the 6-month intervention period, clinical and laboratory parameters and serum osteocalcin levels were determined. Changes in body composition were analyzed by dual-energy X-ray absorptiometry (DXA). In participants of the intervention group, weight loss resulted in improved insulin sensitivity and amelioration of inflammation. Increased serum levels of osteocalcin correlated inversely with BMI (r = −0.63; <i>p</i><i><</i> 0.001), total fat mass (r = −0.58, <i>p</i> < 0.001), total lean mass (r = −0.45, <i>p</i> < 0.001), C-reactive protein (CRP) (r = −0.37; <i>p</i> < 0.01), insulin (r = −0.4; <i>p</i> < 0.001), leptin (r = −0.53; <i>p</i> < 0.001), triglycerides (r = −0.42; <i>p</i> < 0.001), and alanine aminotransferase (ALAT) (r = −0.52; <i>p</i> < 0.001). Regression analysis revealed that osteocalcin was independently associated with changes in CRP but not with changes in insulin concentration, fat mass, or bone mineral density, suggesting that weight loss-induced higher serum osteocalcin is primarily associated with reduced inflammation.https://www.mdpi.com/2218-1989/11/8/526metabolic syndromeosteocalcinlifestyle-induced weight loss |
| spellingShingle | Silke Zimmermann Maria Beatriz Walter Costa Akash Mathew Shruthi Krishnan Jochen G. Schneider Kirsten Roomp Berend Isermann Ronald Biemann Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome Metabolites metabolic syndrome osteocalcin lifestyle-induced weight loss |
| title | Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome |
| title_full | Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome |
| title_fullStr | Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome |
| title_full_unstemmed | Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome |
| title_short | Osteocalcin Is Independently Associated with C-Reactive Protein during Lifestyle-Induced Weight Loss in Metabolic Syndrome |
| title_sort | osteocalcin is independently associated with c reactive protein during lifestyle induced weight loss in metabolic syndrome |
| topic | metabolic syndrome osteocalcin lifestyle-induced weight loss |
| url | https://www.mdpi.com/2218-1989/11/8/526 |
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