The Ins and Outs of RAS Effector Complexes

RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more...

Full description

Bibliographic Details
Main Authors: Christina Kiel, David Matallanas, Walter Kolch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/2/236
_version_ 1797413133462011904
author Christina Kiel
David Matallanas
Walter Kolch
author_facet Christina Kiel
David Matallanas
Walter Kolch
author_sort Christina Kiel
collection DOAJ
description RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more than half of human cancers. Targeting mutant RAS proteins and their downstream oncogenic signaling pathways has been elusive. However, recent results comprising detailed molecular studies, large scale omics studies and computational modeling have painted a new and more comprehensive portrait of RAS signaling that helps us to understand the intricacies of RAS, how its physiological and pathophysiological functions are regulated, and how we can target them. Here, we review these efforts particularly trying to relate the detailed mechanistic studies with global functional studies. We highlight the importance of computational modeling and data integration to derive an actionable understanding of RAS signaling that will allow us to design new mechanism-based therapies for RAS mutated cancers.
first_indexed 2024-03-09T05:13:09Z
format Article
id doaj.art-8cf72cd19f064c53a57bd283f3adfca1
institution Directory Open Access Journal
issn 2218-273X
language English
last_indexed 2024-03-09T05:13:09Z
publishDate 2021-02-01
publisher MDPI AG
record_format Article
series Biomolecules
spelling doaj.art-8cf72cd19f064c53a57bd283f3adfca12023-12-03T12:48:01ZengMDPI AGBiomolecules2218-273X2021-02-0111223610.3390/biom11020236The Ins and Outs of RAS Effector ComplexesChristina Kiel0David Matallanas1Walter Kolch2Systems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandSystems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandSystems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandRAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more than half of human cancers. Targeting mutant RAS proteins and their downstream oncogenic signaling pathways has been elusive. However, recent results comprising detailed molecular studies, large scale omics studies and computational modeling have painted a new and more comprehensive portrait of RAS signaling that helps us to understand the intricacies of RAS, how its physiological and pathophysiological functions are regulated, and how we can target them. Here, we review these efforts particularly trying to relate the detailed mechanistic studies with global functional studies. We highlight the importance of computational modeling and data integration to derive an actionable understanding of RAS signaling that will allow us to design new mechanism-based therapies for RAS mutated cancers.https://www.mdpi.com/2218-273X/11/2/236RAS oncogeneRAS signaling networksRAS in human cancertargeting RAScomputational modelingpersonalized therapies
spellingShingle Christina Kiel
David Matallanas
Walter Kolch
The Ins and Outs of RAS Effector Complexes
Biomolecules
RAS oncogene
RAS signaling networks
RAS in human cancer
targeting RAS
computational modeling
personalized therapies
title The Ins and Outs of RAS Effector Complexes
title_full The Ins and Outs of RAS Effector Complexes
title_fullStr The Ins and Outs of RAS Effector Complexes
title_full_unstemmed The Ins and Outs of RAS Effector Complexes
title_short The Ins and Outs of RAS Effector Complexes
title_sort ins and outs of ras effector complexes
topic RAS oncogene
RAS signaling networks
RAS in human cancer
targeting RAS
computational modeling
personalized therapies
url https://www.mdpi.com/2218-273X/11/2/236
work_keys_str_mv AT christinakiel theinsandoutsofraseffectorcomplexes
AT davidmatallanas theinsandoutsofraseffectorcomplexes
AT walterkolch theinsandoutsofraseffectorcomplexes
AT christinakiel insandoutsofraseffectorcomplexes
AT davidmatallanas insandoutsofraseffectorcomplexes
AT walterkolch insandoutsofraseffectorcomplexes