The Ins and Outs of RAS Effector Complexes
RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more...
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Format: | Article |
Language: | English |
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MDPI AG
2021-02-01
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Series: | Biomolecules |
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Online Access: | https://www.mdpi.com/2218-273X/11/2/236 |
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author | Christina Kiel David Matallanas Walter Kolch |
author_facet | Christina Kiel David Matallanas Walter Kolch |
author_sort | Christina Kiel |
collection | DOAJ |
description | RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more than half of human cancers. Targeting mutant RAS proteins and their downstream oncogenic signaling pathways has been elusive. However, recent results comprising detailed molecular studies, large scale omics studies and computational modeling have painted a new and more comprehensive portrait of RAS signaling that helps us to understand the intricacies of RAS, how its physiological and pathophysiological functions are regulated, and how we can target them. Here, we review these efforts particularly trying to relate the detailed mechanistic studies with global functional studies. We highlight the importance of computational modeling and data integration to derive an actionable understanding of RAS signaling that will allow us to design new mechanism-based therapies for RAS mutated cancers. |
first_indexed | 2024-03-09T05:13:09Z |
format | Article |
id | doaj.art-8cf72cd19f064c53a57bd283f3adfca1 |
institution | Directory Open Access Journal |
issn | 2218-273X |
language | English |
last_indexed | 2024-03-09T05:13:09Z |
publishDate | 2021-02-01 |
publisher | MDPI AG |
record_format | Article |
series | Biomolecules |
spelling | doaj.art-8cf72cd19f064c53a57bd283f3adfca12023-12-03T12:48:01ZengMDPI AGBiomolecules2218-273X2021-02-0111223610.3390/biom11020236The Ins and Outs of RAS Effector ComplexesChristina Kiel0David Matallanas1Walter Kolch2Systems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandSystems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandSystems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, IrelandRAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more than half of human cancers. Targeting mutant RAS proteins and their downstream oncogenic signaling pathways has been elusive. However, recent results comprising detailed molecular studies, large scale omics studies and computational modeling have painted a new and more comprehensive portrait of RAS signaling that helps us to understand the intricacies of RAS, how its physiological and pathophysiological functions are regulated, and how we can target them. Here, we review these efforts particularly trying to relate the detailed mechanistic studies with global functional studies. We highlight the importance of computational modeling and data integration to derive an actionable understanding of RAS signaling that will allow us to design new mechanism-based therapies for RAS mutated cancers.https://www.mdpi.com/2218-273X/11/2/236RAS oncogeneRAS signaling networksRAS in human cancertargeting RAScomputational modelingpersonalized therapies |
spellingShingle | Christina Kiel David Matallanas Walter Kolch The Ins and Outs of RAS Effector Complexes Biomolecules RAS oncogene RAS signaling networks RAS in human cancer targeting RAS computational modeling personalized therapies |
title | The Ins and Outs of RAS Effector Complexes |
title_full | The Ins and Outs of RAS Effector Complexes |
title_fullStr | The Ins and Outs of RAS Effector Complexes |
title_full_unstemmed | The Ins and Outs of RAS Effector Complexes |
title_short | The Ins and Outs of RAS Effector Complexes |
title_sort | ins and outs of ras effector complexes |
topic | RAS oncogene RAS signaling networks RAS in human cancer targeting RAS computational modeling personalized therapies |
url | https://www.mdpi.com/2218-273X/11/2/236 |
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