Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review.
Infectious diseases and underlying medical conditions common to Africa may affect influenza frequency and severity. We conducted a systematic review of published studies on influenza and the following co-infections or co-morbidities that are prevalent in Africa: dengue, malaria, measles, meningococc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0128580 |
| _version_ | 1829498741626765312 |
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| author | Adam L Cohen Meredith McMorrow Sibongile Walaza Cheryl Cohen Stefano Tempia Marissa Alexander-Scott Marc-Alain Widdowson |
| author_facet | Adam L Cohen Meredith McMorrow Sibongile Walaza Cheryl Cohen Stefano Tempia Marissa Alexander-Scott Marc-Alain Widdowson |
| author_sort | Adam L Cohen |
| collection | DOAJ |
| description | Infectious diseases and underlying medical conditions common to Africa may affect influenza frequency and severity. We conducted a systematic review of published studies on influenza and the following co-infections or co-morbidities that are prevalent in Africa: dengue, malaria, measles, meningococcus, Pneumocystis jirovecii pneumonia (PCP), hemoglobinopathies, and malnutrition. Articles were identified except for influenza and PCP. Very few studies were from Africa. Sickle cell disease, dengue, and measles co-infection were found to increase the severity of influenza disease, though this is based on few studies of dengue and measles and the measles study was of low quality. The frequency of influenza was increased among patients with sickle cell disease. Influenza infection increased the frequency of meningococcal disease. Studies on malaria and malnutrition found mixed results. Age-adjusted morbidity and mortality from influenza may be more common in Africa because infections and diseases common in the region lead to more severe outcomes and increase the influenza burden. However, gaps exist in our knowledge about these interactions. |
| first_indexed | 2024-12-16T08:20:12Z |
| format | Article |
| id | doaj.art-8cf80dc0d6d043118c79014c2e935b7b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:20:12Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8cf80dc0d6d043118c79014c2e935b7b2022-12-21T22:38:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012858010.1371/journal.pone.0128580Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review.Adam L CohenMeredith McMorrowSibongile WalazaCheryl CohenStefano TempiaMarissa Alexander-ScottMarc-Alain WiddowsonInfectious diseases and underlying medical conditions common to Africa may affect influenza frequency and severity. We conducted a systematic review of published studies on influenza and the following co-infections or co-morbidities that are prevalent in Africa: dengue, malaria, measles, meningococcus, Pneumocystis jirovecii pneumonia (PCP), hemoglobinopathies, and malnutrition. Articles were identified except for influenza and PCP. Very few studies were from Africa. Sickle cell disease, dengue, and measles co-infection were found to increase the severity of influenza disease, though this is based on few studies of dengue and measles and the measles study was of low quality. The frequency of influenza was increased among patients with sickle cell disease. Influenza infection increased the frequency of meningococcal disease. Studies on malaria and malnutrition found mixed results. Age-adjusted morbidity and mortality from influenza may be more common in Africa because infections and diseases common in the region lead to more severe outcomes and increase the influenza burden. However, gaps exist in our knowledge about these interactions.https://doi.org/10.1371/journal.pone.0128580 |
| spellingShingle | Adam L Cohen Meredith McMorrow Sibongile Walaza Cheryl Cohen Stefano Tempia Marissa Alexander-Scott Marc-Alain Widdowson Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. PLoS ONE |
| title | Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. |
| title_full | Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. |
| title_fullStr | Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. |
| title_full_unstemmed | Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. |
| title_short | Potential Impact of Co-Infections and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review. |
| title_sort | potential impact of co infections and co morbidities prevalent in africa on influenza severity and frequency a systematic review |
| url | https://doi.org/10.1371/journal.pone.0128580 |
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