Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions

Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions

Down syndrome (DS) is one of the most complex genetic disorders in humans and a leading genetic cause of developmental delays and intellectual disabilities. The mouse remains an essential model organism in DS research because human chromosome 21 (Hsa21) is orthologously conserved with three regions...

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Bibliographic Details
Main Authors:	Yichen Li, Zhuo Xing, Tao Yu, Annie Pao, Marcel Daadi, Y. Eugene Yu
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Genes
Subjects:	Down syndrome mouse models coat colors cognitive function
Online Access:	https://www.mdpi.com/2073-4425/12/8/1215

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