A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11538-6 |
| _version_ | 1830145106280185856 |
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| author | Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson |
| author_facet | Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson |
| author_sort | Zhiwei Qin |
| collection | DOAJ |
| description | Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins. |
| first_indexed | 2024-12-17T10:17:21Z |
| format | Article |
| id | doaj.art-8cf9bcdb3d87424c8659c18fd8f71d39 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:17:21Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8cf9bcdb3d87424c8659c18fd8f71d392022-12-21T21:52:53ZengNature PortfolioNature Communications2041-17232019-08-0110111010.1038/s41467-019-11538-6A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesisZhiwei Qin0Rebecca Devine1Matthew I. Hutchings2Barrie Wilkinson3Department of Molecular Microbiology, John Innes CentreSchool of Biological Sciences, University of East AngliaSchool of Biological Sciences, University of East AngliaDepartment of Molecular Microbiology, John Innes CentreFormicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins.https://doi.org/10.1038/s41467-019-11538-6 |
| spellingShingle | Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis Nature Communications |
| title | A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| title_full | A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| title_fullStr | A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| title_full_unstemmed | A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| title_short | A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| title_sort | role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis |
| url | https://doi.org/10.1038/s41467-019-11538-6 |
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