The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks
HIGHLIGHTS • Oral misoprostol is more effective than vaginal misoprostol in cervical ripening as a part of induction of labor. • Oral misoprostol is as safe as vaginal misoprostol. ABSTRACT Objective: To compare Bishop score changes and labor event between oral and vaginal misoprostol in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2023-08-01
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| Series: | Majalah Obstetri dan Ginekologi |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/MOG/article/view/33791 |
| _version_ | 1797635120312614912 |
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| author | Maskasoni Maskasoni Julian Dewantiningrum |
| author_facet | Maskasoni Maskasoni Julian Dewantiningrum |
| author_sort | Maskasoni Maskasoni |
| collection | DOAJ |
| description | HIGHLIGHTS
• Oral misoprostol is more effective than vaginal misoprostol in cervical ripening as a part of induction of labor.
• Oral misoprostol is as safe as vaginal misoprostol.
ABSTRACT
Objective: To compare Bishop score changes and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks.
Materials and Methods: A total of 52 pregnant women with more than 41 weeks of gestation, had a Bishop score less than 5, and were undergoing induction labor were randomly divided into two groups: oral and vaginal misoprostol. In the oral misoprostol group, participants were given 25 mg of misoprostol in a solution with a concentration of 1 ug/ml every 2 hours. In the vaginal misoprostol group, a 25 mg misoprostol tablet was inserted into the posterior fornix every 6 hours. The two groups were compared in terms of Bishop score during the first 6 hours, changes in Bishop score, labor at term events, neonatal outcomes, complications, and side effects after the administration of misoprostol.
Results: The oral group showed significantly higher changes in Bishop score compared to the vaginal group (5.5 vs 3.6; p=0.0001). The median interval times for induction of labor at term, induction at stage II, and induction at birth were found to be shorter in the oral misoprostol group compared to the vaginal group (7.3 hours vs 10.6 hours, 14.0 hours vs 16.8 hours, and 14.6 hours vs 17.6 hours; p=0.002, 0.003, 0.002). Labor at term occurred much more frequently in the oral group (53.8% vs 15.4%). Additionally, the oral misoprostol group had a 3.5 times higher likelihood of experiencing labor at term within the first 6 hours after the initial administration compared to the vaginal group (OR 3.5, 95% CI 1.33-9.23).
Conclusion: Oral administration of misoprostol for cervical ripening has been demonstrated to be more effective than vaginal administration, greater bishop score changes while maintaining an equivalent level of safety. |
| first_indexed | 2024-03-11T12:17:46Z |
| format | Article |
| id | doaj.art-8cfa144eb9df4b4c82b8e1d7649dff49 |
| institution | Directory Open Access Journal |
| issn | 0854-0381 2598-1013 |
| language | English |
| last_indexed | 2024-03-11T12:17:46Z |
| publishDate | 2023-08-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Majalah Obstetri dan Ginekologi |
| spelling | doaj.art-8cfa144eb9df4b4c82b8e1d7649dff492023-11-07T07:30:00ZengUniversitas AirlanggaMajalah Obstetri dan Ginekologi0854-03812598-10132023-08-01312616710.20473/mog.V31I22023.61-6727730The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeksMaskasoni Maskasoni0https://orcid.org/0009-0002-5060-4390Julian Dewantiningrum1https://orcid.org/0000-0002-8937-1646Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Diponegoro - Dr. Kariadi General Academic Hospital, Semarang, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Diponegoro - Dr. Kariadi General Academic Hospital, Semarang, IndonesiaHIGHLIGHTS • Oral misoprostol is more effective than vaginal misoprostol in cervical ripening as a part of induction of labor. • Oral misoprostol is as safe as vaginal misoprostol. ABSTRACT Objective: To compare Bishop score changes and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks. Materials and Methods: A total of 52 pregnant women with more than 41 weeks of gestation, had a Bishop score less than 5, and were undergoing induction labor were randomly divided into two groups: oral and vaginal misoprostol. In the oral misoprostol group, participants were given 25 mg of misoprostol in a solution with a concentration of 1 ug/ml every 2 hours. In the vaginal misoprostol group, a 25 mg misoprostol tablet was inserted into the posterior fornix every 6 hours. The two groups were compared in terms of Bishop score during the first 6 hours, changes in Bishop score, labor at term events, neonatal outcomes, complications, and side effects after the administration of misoprostol. Results: The oral group showed significantly higher changes in Bishop score compared to the vaginal group (5.5 vs 3.6; p=0.0001). The median interval times for induction of labor at term, induction at stage II, and induction at birth were found to be shorter in the oral misoprostol group compared to the vaginal group (7.3 hours vs 10.6 hours, 14.0 hours vs 16.8 hours, and 14.6 hours vs 17.6 hours; p=0.002, 0.003, 0.002). Labor at term occurred much more frequently in the oral group (53.8% vs 15.4%). Additionally, the oral misoprostol group had a 3.5 times higher likelihood of experiencing labor at term within the first 6 hours after the initial administration compared to the vaginal group (OR 3.5, 95% CI 1.33-9.23). Conclusion: Oral administration of misoprostol for cervical ripening has been demonstrated to be more effective than vaginal administration, greater bishop score changes while maintaining an equivalent level of safety.https://e-journal.unair.ac.id/MOG/article/view/33791oral misoprostolbishop scorecervical ripeningmaternal health |
| spellingShingle | Maskasoni Maskasoni Julian Dewantiningrum The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks Majalah Obstetri dan Ginekologi oral misoprostol bishop score cervical ripening maternal health |
| title | The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| title_full | The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| title_fullStr | The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| title_full_unstemmed | The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| title_short | The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| title_sort | difference of bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks |
| topic | oral misoprostol bishop score cervical ripening maternal health |
| url | https://e-journal.unair.ac.id/MOG/article/view/33791 |
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