Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy

Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy

The presence of multiple immunosuppressive targets and insufficient activation and infiltration of cytotoxic T lymphocytes (CTLs) allow tumor cells to escape immune surveillance and disable anti-PD-1/PD-L1 immunotherapy. Nanobiotechnology-engineered autologous tumor vaccines (ATVs) that were camoufl...

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Bibliographic Details
Main Authors: Hong Wu, Hongyan Li, Yiqiang Liu, Jingchen Liang, Qianshi Liu, Zhigang Xu, Zhongzhu Chen, Xia Zhang, Kun Zhang, Chuan Xu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-07-01
Series:Bioactive Materials
Subjects:
Autologous tumor vaccines (ATVs)
Sequential immunotherapy
Immunosuppressive microenvironment
Tumor tropism
Immune escape target
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21005211

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