Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome

Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome

During pregnancy, maternal immune system has to balance tightly between protection against pathogens and tolerance towards a semi-allogeneic organism. Dysfunction of this immune adaptation can lead to severe complications such as pregnancy loss, preeclampsia or fetal growth restriction. In the prese...

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Bibliographic Details
Main Authors: Stefanie Dietz, Julian Schwarz, Ana Velic, Irene González-Menéndez, Leticia Quintanilla-Martinez, Nicolas Casadei, Alexander Marmé, Christian F. Poets, Christian Gille, Natascha Köstlin-Gille
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
HLA-G
Qa-2
pregnancy
myeloid-derived suppressor cells
abortion
preeclampsia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.787468/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.787468/full

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