Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan

Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan

Abstract Background Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxification of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine ki...

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Bibliographic Details
Main Authors: Samina Naz Mukry, Aneeta Shahni, Uzma Zaidi, Tahir Sultan Shamsi
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Cancer
Subjects:
Chronic myeloid leukemia
Nilotinib
Treatment
Drug metabolizing enzymes
Response
Online Access:https://doi.org/10.1186/s12885-022-09605-1

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