Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns

Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns

Abstract Background Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1)) result in tissue-specific symptoms. Given that the minor spliceosome is ubiquitously expressed, we hypothesized that...

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Bibliographic Details
Main Authors: Anouk M. Olthof, Katery C. Hyatt, Rahul N. Kanadia
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Genomics
Subjects:
MIDB
Minor spliceosome
Alternative splicing
Tissue-specificity
Minor intron retention
Online Access:http://link.springer.com/article/10.1186/s12864-019-6046-x

Internet

http://link.springer.com/article/10.1186/s12864-019-6046-x

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