Cervical cancer survival times in Africa
ObjectiveAccessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.981383/full |
| _version_ | 1797984832301563904 |
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| author | Emmanuel Kwateng Drokow Fangnon Firmin Fangninou Clement Yaw Effah Clement Agboyibor Yunfeng Zhang Francisca Arboh Marie-Anne Deku Wu Xinyin Yue Wang Kai Sun |
| author_facet | Emmanuel Kwateng Drokow Fangnon Firmin Fangninou Clement Yaw Effah Clement Agboyibor Yunfeng Zhang Francisca Arboh Marie-Anne Deku Wu Xinyin Yue Wang Kai Sun |
| author_sort | Emmanuel Kwateng Drokow |
| collection | DOAJ |
| description | ObjectiveAccessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age.Methods and materialsMajor electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P).ResultsA total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%).ConclusionTo enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required. |
| first_indexed | 2024-04-11T07:07:56Z |
| format | Article |
| id | doaj.art-8d001e9880784b1a866a9b1d823ed792 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T07:07:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-8d001e9880784b1a866a9b1d823ed7922022-12-22T04:38:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-11-011010.3389/fpubh.2022.981383981383Cervical cancer survival times in AfricaEmmanuel Kwateng Drokow0Fangnon Firmin Fangninou1Clement Yaw Effah2Clement Agboyibor3Yunfeng Zhang4Francisca Arboh5Marie-Anne Deku6Wu Xinyin7Yue Wang8Kai Sun9Department of Radiation Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, ChinaState Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze River Water, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou, ChinaSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynaecology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Management Science and Engineering, Jiangsu University, Zhenjiang, ChinaBinzhou Medical University, Yantai, ChinaXiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Obstetrics and Gynaecology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Hematology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, ChinaObjectiveAccessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age.Methods and materialsMajor electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P).ResultsA total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%).ConclusionTo enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required.https://www.frontiersin.org/articles/10.3389/fpubh.2022.981383/fullcervical cancersurvival rateAfricameta-analysissystematic review |
| spellingShingle | Emmanuel Kwateng Drokow Fangnon Firmin Fangninou Clement Yaw Effah Clement Agboyibor Yunfeng Zhang Francisca Arboh Marie-Anne Deku Wu Xinyin Yue Wang Kai Sun Cervical cancer survival times in Africa Frontiers in Public Health cervical cancer survival rate Africa meta-analysis systematic review |
| title | Cervical cancer survival times in Africa |
| title_full | Cervical cancer survival times in Africa |
| title_fullStr | Cervical cancer survival times in Africa |
| title_full_unstemmed | Cervical cancer survival times in Africa |
| title_short | Cervical cancer survival times in Africa |
| title_sort | cervical cancer survival times in africa |
| topic | cervical cancer survival rate Africa meta-analysis systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.981383/full |
| work_keys_str_mv | AT emmanuelkwatengdrokow cervicalcancersurvivaltimesinafrica AT fangnonfirminfangninou cervicalcancersurvivaltimesinafrica AT clementyaweffah cervicalcancersurvivaltimesinafrica AT clementagboyibor cervicalcancersurvivaltimesinafrica AT yunfengzhang cervicalcancersurvivaltimesinafrica AT franciscaarboh cervicalcancersurvivaltimesinafrica AT marieannedeku cervicalcancersurvivaltimesinafrica AT wuxinyin cervicalcancersurvivaltimesinafrica AT yuewang cervicalcancersurvivaltimesinafrica AT kaisun cervicalcancersurvivaltimesinafrica |