The UPR Maintains Proteostasis and the Viability and Function of Hippocampal Neurons in Adult Mice

The UPR Maintains Proteostasis and the Viability and Function of Hippocampal Neurons in Adult Mice

The unfolded protein response (UPR), which comprises three branches: PERK, ATF6α, and IRE1, is a major mechanism for maintaining cellular proteostasis. Many studies show that the UPR is a major player in regulating neuron viability and function in various neurodegenerative diseases; however, its rol...

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Bibliographic Details
Main Authors: Pingting Liu, Md Razaul Karim, Ana Covelo, Yuan Yue, Michael K. Lee, Wensheng Lin
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
UPR
neuron
proteostasis
autophagy
lysosome
tau
Online Access:https://www.mdpi.com/1422-0067/24/14/11542

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