Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review
Two-dimensional nanostructures (2DNS) attract tremendous interest and have emerged as potential materials for a variety of applications, including biomolecule sensing, due to their high surface-to-volume ratio, tuneable optical and electronic properties. Advancements in the engineering of 2DNS and a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/102 |
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| author | K. A. Esther Jebakumari N. K. Murugasenapathi Tamilarasan Palanisamy |
| author_facet | K. A. Esther Jebakumari N. K. Murugasenapathi Tamilarasan Palanisamy |
| author_sort | K. A. Esther Jebakumari |
| collection | DOAJ |
| description | Two-dimensional nanostructures (2DNS) attract tremendous interest and have emerged as potential materials for a variety of applications, including biomolecule sensing, due to their high surface-to-volume ratio, tuneable optical and electronic properties. Advancements in the engineering of 2DNS and associated technologies have opened up new opportunities. Surface-enhanced Raman scattering (SERS) is a rapid, highly sensitive, non-destructive analytical technique with exceptional signal amplification potential. Several structurally and chemically engineered 2DNS with added advantages (e.g., π–π* interaction), over plasmonic SERS substrates, have been developed specifically towards biomolecule sensing in a complex matrix, such as biological fluids. This review focuses on the recent developments of 2DNS-SERS substrates for biomolecule sensor applications. The recent advancements in engineered 2DNS, particularly for SERS substrates, have been systematically surveyed. In SERS substrates, 2DNS are used as either a standalone signal enhancer or as support for the dispersion of plasmonic nanostructures. The current challenges and future opportunities in this synergetic combination have also been discussed. Given the prospects in the design and preparation of newer 2DNS, this review can give a critical view on the current status, challenges and opportunities to extrapolate their applications in biomolecule detection. |
| first_indexed | 2024-03-09T13:24:28Z |
| format | Article |
| id | doaj.art-8d01e63955724ba7ba83e0c52e689a4c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:24:28Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-8d01e63955724ba7ba83e0c52e689a4c2023-11-30T21:25:31ZengMDPI AGBiosensors2079-63742023-01-0113110210.3390/bios13010102Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A ReviewK. A. Esther Jebakumari0N. K. Murugasenapathi1Tamilarasan Palanisamy2Electrodics and Electrocatalysis Division (EEC), CSIR—Central Electrochemical Research Institute (CECRI), Karaikudi 630003, Tamil Nadu, IndiaElectrodics and Electrocatalysis Division (EEC), CSIR—Central Electrochemical Research Institute (CECRI), Karaikudi 630003, Tamil Nadu, IndiaElectrodics and Electrocatalysis Division (EEC), CSIR—Central Electrochemical Research Institute (CECRI), Karaikudi 630003, Tamil Nadu, IndiaTwo-dimensional nanostructures (2DNS) attract tremendous interest and have emerged as potential materials for a variety of applications, including biomolecule sensing, due to their high surface-to-volume ratio, tuneable optical and electronic properties. Advancements in the engineering of 2DNS and associated technologies have opened up new opportunities. Surface-enhanced Raman scattering (SERS) is a rapid, highly sensitive, non-destructive analytical technique with exceptional signal amplification potential. Several structurally and chemically engineered 2DNS with added advantages (e.g., π–π* interaction), over plasmonic SERS substrates, have been developed specifically towards biomolecule sensing in a complex matrix, such as biological fluids. This review focuses on the recent developments of 2DNS-SERS substrates for biomolecule sensor applications. The recent advancements in engineered 2DNS, particularly for SERS substrates, have been systematically surveyed. In SERS substrates, 2DNS are used as either a standalone signal enhancer or as support for the dispersion of plasmonic nanostructures. The current challenges and future opportunities in this synergetic combination have also been discussed. Given the prospects in the design and preparation of newer 2DNS, this review can give a critical view on the current status, challenges and opportunities to extrapolate their applications in biomolecule detection.https://www.mdpi.com/2079-6374/13/1/102surface-enhanced Raman spectroscopychemical enhancementtwo-dimensional nanostructuresengineered substratesbiomolecule sensor |
| spellingShingle | K. A. Esther Jebakumari N. K. Murugasenapathi Tamilarasan Palanisamy Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review Biosensors surface-enhanced Raman spectroscopy chemical enhancement two-dimensional nanostructures engineered substrates biomolecule sensor |
| title | Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review |
| title_full | Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review |
| title_fullStr | Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review |
| title_full_unstemmed | Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review |
| title_short | Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review |
| title_sort | engineered two dimensional nanostructures as sers substrates for biomolecule sensing a review |
| topic | surface-enhanced Raman spectroscopy chemical enhancement two-dimensional nanostructures engineered substrates biomolecule sensor |
| url | https://www.mdpi.com/2079-6374/13/1/102 |
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