Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study
Background: Ulcerative colitis (UC) is an immune-mediated inflammatory disease that is associated with an increased incidence of cardiovascular events. Several inflammatory mechanisms associated with the pathogenesis of UC are involved in the initiation and progression of aortic aneurysms (AAs). We...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Medical Sciences |
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| Online Access: | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2019;volume=39;issue=2;spage=74;epage=80;aulast= |
| _version_ | 1819241213605183488 |
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| author | Chih-Jen Yang Chi-Hsiang Chung Sy-Jou Chen Wen-I Liao Yi-Da Tsai Jen-Chun Wang Wu-Chien Chien |
| author_facet | Chih-Jen Yang Chi-Hsiang Chung Sy-Jou Chen Wen-I Liao Yi-Da Tsai Jen-Chun Wang Wu-Chien Chien |
| author_sort | Chih-Jen Yang |
| collection | DOAJ |
| description | Background: Ulcerative colitis (UC) is an immune-mediated inflammatory disease that is associated with an increased incidence of cardiovascular events. Several inflammatory mechanisms associated with the pathogenesis of UC are involved in the initiation and progression of aortic aneurysms (AAs). We aimed to evaluate whether patients with UC have an increased risk of AA. Methods: We conducted a retrospective cohort study using data extracted from Taiwan's National Health Insurance Research Database. All medical conditions for each case and control subject were categorized using the International Classification of Diseases, 9th Revision. Hazard ratios and 95% confidence intervals for associations between UC and AA were estimated using the Cox regression adjusted for comorbidities. Results: Our analyses included 7256 UC patients and propensity score-matched controls. Compared to the controls, UC patients exhibited a significantly increased risk of developing an AA (adjusted odds ratio = 3.154, P < 0.001). Conclusion: UC patients have an increased risk of developing an AA, and healthcare professionals should be aware of this risk when treating UC patients. Aortic surveillance may be required for UC patients. |
| first_indexed | 2024-12-23T14:20:20Z |
| format | Article |
| id | doaj.art-8d029d9d894b45e1be9ade81886a4bcb |
| institution | Directory Open Access Journal |
| issn | 1011-4564 |
| language | English |
| last_indexed | 2024-12-23T14:20:20Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Sciences |
| spelling | doaj.art-8d029d9d894b45e1be9ade81886a4bcb2022-12-21T17:43:48ZengWolters Kluwer Medknow PublicationsJournal of Medical Sciences1011-45642019-01-01392748010.4103/jmedsci.jmedsci_99_18Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort studyChih-Jen YangChi-Hsiang ChungSy-Jou ChenWen-I LiaoYi-Da TsaiJen-Chun WangWu-Chien ChienBackground: Ulcerative colitis (UC) is an immune-mediated inflammatory disease that is associated with an increased incidence of cardiovascular events. Several inflammatory mechanisms associated with the pathogenesis of UC are involved in the initiation and progression of aortic aneurysms (AAs). We aimed to evaluate whether patients with UC have an increased risk of AA. Methods: We conducted a retrospective cohort study using data extracted from Taiwan's National Health Insurance Research Database. All medical conditions for each case and control subject were categorized using the International Classification of Diseases, 9th Revision. Hazard ratios and 95% confidence intervals for associations between UC and AA were estimated using the Cox regression adjusted for comorbidities. Results: Our analyses included 7256 UC patients and propensity score-matched controls. Compared to the controls, UC patients exhibited a significantly increased risk of developing an AA (adjusted odds ratio = 3.154, P < 0.001). Conclusion: UC patients have an increased risk of developing an AA, and healthcare professionals should be aware of this risk when treating UC patients. Aortic surveillance may be required for UC patients.http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2019;volume=39;issue=2;spage=74;epage=80;aulast=Ulcerative colitisaortic aneurysminflammatory bowel disease |
| spellingShingle | Chih-Jen Yang Chi-Hsiang Chung Sy-Jou Chen Wen-I Liao Yi-Da Tsai Jen-Chun Wang Wu-Chien Chien Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study Journal of Medical Sciences Ulcerative colitis aortic aneurysm inflammatory bowel disease |
| title | Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study |
| title_full | Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study |
| title_fullStr | Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study |
| title_full_unstemmed | Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study |
| title_short | Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study |
| title_sort | association between aortic aneurysm and ulcerative colitis a nationwide taiwanese retrospective cohort study |
| topic | Ulcerative colitis aortic aneurysm inflammatory bowel disease |
| url | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2019;volume=39;issue=2;spage=74;epage=80;aulast= |
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