Research progress on the role of microRNA in diabetic osteoporosis
Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-02-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-311.pdf |
| _version_ | 1797366359524376576 |
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| author | YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu |
| author_facet | YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu |
| author_sort | YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu |
| collection | DOAJ |
| description | Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β-catenin signaling pathway, leading to the occurrence and development of DOP. Exploring the role of miRNA in DOP can provide new ideas for the diagnosis and treatment of DOP. |
| first_indexed | 2024-03-08T17:03:07Z |
| format | Article |
| id | doaj.art-8d0677da72ca42eebba853bd21045afd |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:03:07Z |
| publishDate | 2023-02-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-8d0677da72ca42eebba853bd21045afd2024-01-04T07:27:29ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-02-0143231131610.16352/j.issn.1001-6325.2023.02.311Research progress on the role of microRNA in diabetic osteoporosisYANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu01. Department of Endocrinology, the First Clinical Medical College,Lanzhou University,Lanzhou 730000; ;2. Department of Endocrinology,the First Hospital,Lanzhou University,Lanzhou 730000,ChinaDiabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β-catenin signaling pathway, leading to the occurrence and development of DOP. Exploring the role of miRNA in DOP can provide new ideas for the diagnosis and treatment of DOP.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-311.pdfdiabetes mellitus|osteoporosis|micrornas|wnt signaling pathway|mesenchymal stem cells |
| spellingShingle | YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu Research progress on the role of microRNA in diabetic osteoporosis Jichu yixue yu linchuang diabetes mellitus|osteoporosis|micrornas|wnt signaling pathway|mesenchymal stem cells |
| title | Research progress on the role of microRNA in diabetic osteoporosis |
| title_full | Research progress on the role of microRNA in diabetic osteoporosis |
| title_fullStr | Research progress on the role of microRNA in diabetic osteoporosis |
| title_full_unstemmed | Research progress on the role of microRNA in diabetic osteoporosis |
| title_short | Research progress on the role of microRNA in diabetic osteoporosis |
| title_sort | research progress on the role of microrna in diabetic osteoporosis |
| topic | diabetes mellitus|osteoporosis|micrornas|wnt signaling pathway|mesenchymal stem cells |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-311.pdf |
| work_keys_str_mv | AT yangmengdidingyuluwangyujiehefengyingsunlinnanzhendonghu researchprogressontheroleofmicrornaindiabeticosteoporosis |