Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?
Abstract Background Our study aims to reveal whether the low b-values distribution, high b-values upper limit, and the number of excitation (NEX) influence the accuracy of the intravoxel incoherent motion (IVIM) parameter derived from multi-b-value diffusion-weighted imaging (DWI) in the brain. Meth...
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-020-0419-0 |
| _version_ | 1818392900215504896 |
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| author | Yu-Chuan Hu Lin-Feng Yan Yu Han Shi-Jun Duan Qian Sun Gang-Feng Li Wen Wang Xiao-Cheng Wei Dan-Dan Zheng Guang-Bin Cui |
| author_facet | Yu-Chuan Hu Lin-Feng Yan Yu Han Shi-Jun Duan Qian Sun Gang-Feng Li Wen Wang Xiao-Cheng Wei Dan-Dan Zheng Guang-Bin Cui |
| author_sort | Yu-Chuan Hu |
| collection | DOAJ |
| description | Abstract Background Our study aims to reveal whether the low b-values distribution, high b-values upper limit, and the number of excitation (NEX) influence the accuracy of the intravoxel incoherent motion (IVIM) parameter derived from multi-b-value diffusion-weighted imaging (DWI) in the brain. Methods This prospective study was approved by the local Ethics Committee and informed consent was obtained from each participant. The five consecutive multi-b DWI with different b-value protocols (0–3500 s/mm2) were performed in 22 male healthy volunteers on a 3.0-T MRI system. The IVIM parameters from normal white matter (WM) and gray matter (GM) including slow diffusion coefficient (D), fast perfusion coefficient (D*) and perfusion fraction (f) were compared for differences among defined groups with different IVIM protocols by one-way ANOVA. Results The D* and f value of WM or GM in groups with less low b-values distribution (less than or equal to 5 b-values) were significantly lower than ones in any other group with more low b-values distribution (all P < 0.05), but no significant differences among groups with more low b-values distribution (P > 0.05). In addition, no significant differences in the D, D* and f value of WM or GM were found between group with one and more NEX of low b-values distribution (all P > 0.05). IVIM parameters in normal WM and GM strongly depended on the choice of the high b-value upper limit. Conclusions Metrics of IVIM parameters can be affected by low and high b value distribution. Eight low b-values distribution with high b-value upper limit of 800–1000 s/mm2 may be the relatively proper set when performing brain IVIM studies. |
| first_indexed | 2024-12-14T05:36:46Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-12-14T05:36:46Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-8d067b59afde43ef837ee1e2466eb5a82022-12-21T23:15:08ZengBMCBMC Medical Imaging1471-23422020-02-012011910.1186/s12880-020-0419-0Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?Yu-Chuan Hu0Lin-Feng Yan1Yu Han2Shi-Jun Duan3Qian Sun4Gang-Feng Li5Wen Wang6Xiao-Cheng Wei7Dan-Dan Zheng8Guang-Bin Cui9Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)MR Research China, GE Healthcare ChinaMR Research China, GE Healthcare ChinaDepartment of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University)Abstract Background Our study aims to reveal whether the low b-values distribution, high b-values upper limit, and the number of excitation (NEX) influence the accuracy of the intravoxel incoherent motion (IVIM) parameter derived from multi-b-value diffusion-weighted imaging (DWI) in the brain. Methods This prospective study was approved by the local Ethics Committee and informed consent was obtained from each participant. The five consecutive multi-b DWI with different b-value protocols (0–3500 s/mm2) were performed in 22 male healthy volunteers on a 3.0-T MRI system. The IVIM parameters from normal white matter (WM) and gray matter (GM) including slow diffusion coefficient (D), fast perfusion coefficient (D*) and perfusion fraction (f) were compared for differences among defined groups with different IVIM protocols by one-way ANOVA. Results The D* and f value of WM or GM in groups with less low b-values distribution (less than or equal to 5 b-values) were significantly lower than ones in any other group with more low b-values distribution (all P < 0.05), but no significant differences among groups with more low b-values distribution (P > 0.05). In addition, no significant differences in the D, D* and f value of WM or GM were found between group with one and more NEX of low b-values distribution (all P > 0.05). IVIM parameters in normal WM and GM strongly depended on the choice of the high b-value upper limit. Conclusions Metrics of IVIM parameters can be affected by low and high b value distribution. Eight low b-values distribution with high b-value upper limit of 800–1000 s/mm2 may be the relatively proper set when performing brain IVIM studies.https://doi.org/10.1186/s12880-020-0419-0Intravoxel incoherent motionB-valuePseudodiffusionBrainDiffusion weighted imagingNumber of excitation |
| spellingShingle | Yu-Chuan Hu Lin-Feng Yan Yu Han Shi-Jun Duan Qian Sun Gang-Feng Li Wen Wang Xiao-Cheng Wei Dan-Dan Zheng Guang-Bin Cui Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? BMC Medical Imaging Intravoxel incoherent motion B-value Pseudodiffusion Brain Diffusion weighted imaging Number of excitation |
| title | Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? |
| title_full | Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? |
| title_fullStr | Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? |
| title_full_unstemmed | Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? |
| title_short | Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain? |
| title_sort | can the low and high b value distribution influence the pseudodiffusion parameter derived from ivim dwi in normal brain |
| topic | Intravoxel incoherent motion B-value Pseudodiffusion Brain Diffusion weighted imaging Number of excitation |
| url | https://doi.org/10.1186/s12880-020-0419-0 |
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