Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography
In this single-center cross-sectional study on patients undergoing coronary computed tomography angiography (CCTA), we assessed the prognostic significance of metabolic dysfunction associated steatotic liver disease (MASLD), metabolic syndrome (MetS), and CCTA-derived parameters for predicting major...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/11/3/77 |
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| author | Rares Ilie Orzan Rares Ioan Gligor Renata Agoston Carmen Cionca Alexandru Zlibut Raluca Pais Andrada Seicean Lucia Agoston-Coldea |
| author_facet | Rares Ilie Orzan Rares Ioan Gligor Renata Agoston Carmen Cionca Alexandru Zlibut Raluca Pais Andrada Seicean Lucia Agoston-Coldea |
| author_sort | Rares Ilie Orzan |
| collection | DOAJ |
| description | In this single-center cross-sectional study on patients undergoing coronary computed tomography angiography (CCTA), we assessed the prognostic significance of metabolic dysfunction associated steatotic liver disease (MASLD), metabolic syndrome (MetS), and CCTA-derived parameters for predicting major adverse cardiovascular events (MACE). Over a mean follow-up of 26.9 months, 2038 patients were analyzed, with 361 (17.7%) experiencing MACE. MASLD was associated with a higher MACE incidence (25.90% vs. 14.71% without MASLD, <i>p</i> < 0.001). Cox regression revealed significant associations between MASLD, coronary calcium score (CCS), number of plaques (NoP), epicardial fat volume (EFV), and MACE, with hazard ratios of 1.843, 1.001, 1.097, and 1.035, respectively (<i>p</i> < 0.001 for all). A composite risk score integrating CCS, NoP, EFV, and MASLD demonstrated superior predictive value for MACE (AUC = 0.948) compared to individual variables (<i>p</i> < 0.0001 for all). In conclusion, MASLD is linked to an elevated risk of MACE, and a comprehensive risk-scoring system incorporating imaging and clinical factors enhances MACE prediction accuracy. |
| first_indexed | 2024-04-24T18:09:21Z |
| format | Article |
| id | doaj.art-8d071927c5a7402f9ab53f7cfb2b6f33 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-04-24T18:09:21Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-8d071927c5a7402f9ab53f7cfb2b6f332024-03-27T13:47:32ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-02-011137710.3390/jcdd11030077Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography AngiographyRares Ilie Orzan0Rares Ioan Gligor1Renata Agoston2Carmen Cionca3Alexandru Zlibut4Raluca Pais5Andrada Seicean6Lucia Agoston-Coldea7Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaInstitut de Cardiométabolisme et Nutrition, Hôpital Pitié Salpetrière, Assistance Publique Hôpitaux de Paris, 75013 Paris, FranceDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaIn this single-center cross-sectional study on patients undergoing coronary computed tomography angiography (CCTA), we assessed the prognostic significance of metabolic dysfunction associated steatotic liver disease (MASLD), metabolic syndrome (MetS), and CCTA-derived parameters for predicting major adverse cardiovascular events (MACE). Over a mean follow-up of 26.9 months, 2038 patients were analyzed, with 361 (17.7%) experiencing MACE. MASLD was associated with a higher MACE incidence (25.90% vs. 14.71% without MASLD, <i>p</i> < 0.001). Cox regression revealed significant associations between MASLD, coronary calcium score (CCS), number of plaques (NoP), epicardial fat volume (EFV), and MACE, with hazard ratios of 1.843, 1.001, 1.097, and 1.035, respectively (<i>p</i> < 0.001 for all). A composite risk score integrating CCS, NoP, EFV, and MASLD demonstrated superior predictive value for MACE (AUC = 0.948) compared to individual variables (<i>p</i> < 0.0001 for all). In conclusion, MASLD is linked to an elevated risk of MACE, and a comprehensive risk-scoring system incorporating imaging and clinical factors enhances MACE prediction accuracy.https://www.mdpi.com/2308-3425/11/3/77fatty liver diseasemetabolic dysfunctioncoronary artery diseasecardiac computed tomographyepicardial fat volume |
| spellingShingle | Rares Ilie Orzan Rares Ioan Gligor Renata Agoston Carmen Cionca Alexandru Zlibut Raluca Pais Andrada Seicean Lucia Agoston-Coldea Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography Journal of Cardiovascular Development and Disease fatty liver disease metabolic dysfunction coronary artery disease cardiac computed tomography epicardial fat volume |
| title | Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography |
| title_full | Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography |
| title_fullStr | Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography |
| title_full_unstemmed | Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography |
| title_short | Metabolic Dysfunction Associated Liver Disease in Patients Undergoing Coronary Computed Tomography Angiography |
| title_sort | metabolic dysfunction associated liver disease in patients undergoing coronary computed tomography angiography |
| topic | fatty liver disease metabolic dysfunction coronary artery disease cardiac computed tomography epicardial fat volume |
| url | https://www.mdpi.com/2308-3425/11/3/77 |
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