Variable habitat conditions drive species covariation in the human microbiota.
Two species with similar resource requirements respond in a characteristic way to variations in their habitat-their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the huma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-04-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC5407567?pdf=render |
| _version_ | 1811217157262934016 |
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| author | Charles K Fisher Thierry Mora Aleksandra M Walczak |
| author_facet | Charles K Fisher Thierry Mora Aleksandra M Walczak |
| author_sort | Charles K Fisher |
| collection | DOAJ |
| description | Two species with similar resource requirements respond in a characteristic way to variations in their habitat-their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the human population. Our mathematical framework shows that habitat fluctuations are sufficient for explaining intra-bodysite correlations in relative species abundances from the Human Microbiome Project. We explicitly show that the relative abundances of closely related species are positively correlated and can be predicted from taxonomic relationships. We identify a small set of functional pathways related to metabolism and maintenance of the cell wall that form the basis of a common resource sharing niche space of the human microbiota. |
| first_indexed | 2024-04-12T06:50:42Z |
| format | Article |
| id | doaj.art-8d07b2c97fb44685893c4a4595b6d6c1 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-12T06:50:42Z |
| publishDate | 2017-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-8d07b2c97fb44685893c4a4595b6d6c12022-12-22T03:43:24ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582017-04-01134e100543510.1371/journal.pcbi.1005435Variable habitat conditions drive species covariation in the human microbiota.Charles K FisherThierry MoraAleksandra M WalczakTwo species with similar resource requirements respond in a characteristic way to variations in their habitat-their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the human population. Our mathematical framework shows that habitat fluctuations are sufficient for explaining intra-bodysite correlations in relative species abundances from the Human Microbiome Project. We explicitly show that the relative abundances of closely related species are positively correlated and can be predicted from taxonomic relationships. We identify a small set of functional pathways related to metabolism and maintenance of the cell wall that form the basis of a common resource sharing niche space of the human microbiota.http://europepmc.org/articles/PMC5407567?pdf=render |
| spellingShingle | Charles K Fisher Thierry Mora Aleksandra M Walczak Variable habitat conditions drive species covariation in the human microbiota. PLoS Computational Biology |
| title | Variable habitat conditions drive species covariation in the human microbiota. |
| title_full | Variable habitat conditions drive species covariation in the human microbiota. |
| title_fullStr | Variable habitat conditions drive species covariation in the human microbiota. |
| title_full_unstemmed | Variable habitat conditions drive species covariation in the human microbiota. |
| title_short | Variable habitat conditions drive species covariation in the human microbiota. |
| title_sort | variable habitat conditions drive species covariation in the human microbiota |
| url | http://europepmc.org/articles/PMC5407567?pdf=render |
| work_keys_str_mv | AT charleskfisher variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota AT thierrymora variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota AT aleksandramwalczak variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota |