Non-POU Domain-Containing Octomer-Binding (NONO) protein expression and stability promotes the tumorigenicity and activation of Akt/MAPK/β-catenin pathways in human breast cancer cells

Non-POU Domain-Containing Octomer-Binding (NONO) protein expression and stability promotes the tumorigenicity and activation of Akt/MAPK/β-catenin pathways in human breast cancer cells

Abstract Breast cancer is one of the most common cancers with a high mortality rate, underscoring the need to identify new therapeutic targets. Here we report that non-POU domain-containing octamer-binding (NONO) protein is overexpressed in breast cancer and validated the interaction of the WW domai...

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Bibliographic Details
Main Authors: Bilal Ahmad Lone, Fouzia Siraj, Ira Sharma, Shweta Verma, Shibendra Kumar Lal Karna, Faiz Ahmad, Preeti Nagar, Chetana Sachidanandan, Yuba Raj Pokharel
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
NONO
PIN1
MAPK/β-catenin
P53
Metastasis
Online Access:https://doi.org/10.1186/s12964-023-01179-0

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