CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

Cellular ESCRT machinery plays pivotal role in HIV-1 budding and release. Extracellular stimuli that modulate HIV-1 egress are currently unknown. We found that CCL2 induced by HIV-1 clade B (HIV-1B) infection of macrophages enhanced virus production, while CCL2 immuno-depletion reversed this effect....

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Bibliographic Details
Main Authors: David O Ajasin, Vasudev R Rao, Xuhong Wu, Santhamani Ramasamy, Mario Pujato, Arthur P Ruiz, Andras Fiser, Anne R Bresnick, Ganjam V Kalpana, Vinayaka R Prasad
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
CCL2
ALIX
HIV-1
HIV-1 clade C
Gag p6
late domain
Online Access:https://elifesciences.org/articles/35546

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