Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity
Abstract Background Prevalence of overall cognitive impairment based on each participant’s performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a neuropsychological battery administe...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-023-01317-3 |
| _version_ | 1797453619075743744 |
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| author | Megan E. O’Connell Helena Kadlec Lauren E. Griffith Christina Wolfson Geva Maimon Vanessa Taler Susan Kirkland Parminder Raina |
| author_facet | Megan E. O’Connell Helena Kadlec Lauren E. Griffith Christina Wolfson Geva Maimon Vanessa Taler Susan Kirkland Parminder Raina |
| author_sort | Megan E. O’Connell |
| collection | DOAJ |
| description | Abstract Background Prevalence of overall cognitive impairment based on each participant’s performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a neuropsychological battery administered in a population-based study. This CII approximates the clinical practice of interpretation across a neuropsychological battery and can be applied to any neuropsychological dataset. Methods Using data from participants aged 45–85 in the Canadian Longitudinal Study on Aging receiving a telephone-administered neuropsychological battery (Tracking, N = 21,241) or a longer in-person battery (Comprehensive, N = 30,097), impairment was determined for each neuropsychological test based on comparison with normative data. We adjusted for the joint probability of abnormally low scores on multiple neuropsychological tests using baserates of low scores demonstrated in the normative samples and created a dichotomous CII (i.e., cognitive impairment vs no cognitive impairment). Convergent and discriminant validity of the CII were assessed with logistic regression analyses. Results Using the CII, the prevalence of cognitive impairment was 4.3% in the Tracking and 5.0% in the Comprehensive cohorts. The CII demonstrated strong convergent and discriminant validity. Conclusions The approach for the CII is a feasible method to identify participants who demonstrate cognitive impairment on a battery of tests. These methods can be applied in other epidemiological studies that use neuropsychological batteries. |
| first_indexed | 2024-03-09T15:25:26Z |
| format | Article |
| id | doaj.art-8d0a9729473743e7a7b974f180ffdf94 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-03-09T15:25:26Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-8d0a9729473743e7a7b974f180ffdf942023-11-26T12:32:51ZengBMCAlzheimer’s Research & Therapy1758-91932023-10-0115111210.1186/s13195-023-01317-3Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validityMegan E. O’Connell0Helena Kadlec1Lauren E. Griffith2Christina Wolfson3Geva Maimon4Vanessa Taler5Susan Kirkland6Parminder Raina7Department of Psychology and Health Studies, University of SaskatchewanInstitute On Aging & Lifelong Health, University of Victoria, STN CSCDepartment of Health Research Methods, Evidence, and Impact, McMaster UniversityDepartment of Epidemiology and Biostatistics and Occupational Health, School of Population and Global Health, McGill UniversityCLSA Data Curation Centre, Research Institute of the McGill University Health CentreSchool of Psychology, University of OttawaDepartment of Community Health and Epidemiology, Dalhousie UniversityDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster Institute for Research On Aging & Labarge Centre for Mobility in Aging, McMaster University, MIP Suite 309AAbstract Background Prevalence of overall cognitive impairment based on each participant’s performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a neuropsychological battery administered in a population-based study. This CII approximates the clinical practice of interpretation across a neuropsychological battery and can be applied to any neuropsychological dataset. Methods Using data from participants aged 45–85 in the Canadian Longitudinal Study on Aging receiving a telephone-administered neuropsychological battery (Tracking, N = 21,241) or a longer in-person battery (Comprehensive, N = 30,097), impairment was determined for each neuropsychological test based on comparison with normative data. We adjusted for the joint probability of abnormally low scores on multiple neuropsychological tests using baserates of low scores demonstrated in the normative samples and created a dichotomous CII (i.e., cognitive impairment vs no cognitive impairment). Convergent and discriminant validity of the CII were assessed with logistic regression analyses. Results Using the CII, the prevalence of cognitive impairment was 4.3% in the Tracking and 5.0% in the Comprehensive cohorts. The CII demonstrated strong convergent and discriminant validity. Conclusions The approach for the CII is a feasible method to identify participants who demonstrate cognitive impairment on a battery of tests. These methods can be applied in other epidemiological studies that use neuropsychological batteries.https://doi.org/10.1186/s13195-023-01317-3BaseratesMedical conditionsNormative dataMeasurementCognitive impairment indicatorNeuropsychological battery |
| spellingShingle | Megan E. O’Connell Helena Kadlec Lauren E. Griffith Christina Wolfson Geva Maimon Vanessa Taler Susan Kirkland Parminder Raina Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity Alzheimer’s Research & Therapy Baserates Medical conditions Normative data Measurement Cognitive impairment indicator Neuropsychological battery |
| title | Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity |
| title_full | Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity |
| title_fullStr | Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity |
| title_full_unstemmed | Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity |
| title_short | Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity |
| title_sort | cognitive impairment indicator for the neuropsychological test batteries in the canadian longitudinal study on aging definition and evidence for validity |
| topic | Baserates Medical conditions Normative data Measurement Cognitive impairment indicator Neuropsychological battery |
| url | https://doi.org/10.1186/s13195-023-01317-3 |
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