Pharmacokinetic profile of tert-butylaminoethanethiol
A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to furth...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1990-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300013 |
| _version_ | 1827879426256273408 |
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| author | M. H. Guerra Andrade A. C. T. Freire D. L. Nelson |
| author_facet | M. H. Guerra Andrade A. C. T. Freire D. L. Nelson |
| author_sort | M. H. Guerra Andrade |
| collection | DOAJ |
| description | A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug: area under the intravenous curve (AUC i.v.): 443(+ ou -) 24.0; AUC oral: 85.5(+ ou -) 14.5 ug min.ml(elevado a -1); elimination rate constant: 0.069(+ ou -) 0.0055 min(elevado a -1), biological half-life: 10.0(+ ou -) 0.80 min; distribution volume 1.15(+ ou -) 0.15 ml/g; biodisponibility: 0.19(+ ou -) 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound. |
| first_indexed | 2024-03-12T18:05:29Z |
| format | Article |
| id | doaj.art-8d0af7425ea24281ae65af43eb5b9904 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:29Z |
| publishDate | 1990-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-8d0af7425ea24281ae65af43eb5b99042023-08-02T09:28:26ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601990-09-0185335335610.1590/S0074-02761990000300013Pharmacokinetic profile of tert-butylaminoethanethiolM. H. Guerra AndradeA. C. T. FreireD. L. NelsonA preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug: area under the intravenous curve (AUC i.v.): 443(+ ou -) 24.0; AUC oral: 85.5(+ ou -) 14.5 ug min.ml(elevado a -1); elimination rate constant: 0.069(+ ou -) 0.0055 min(elevado a -1), biological half-life: 10.0(+ ou -) 0.80 min; distribution volume 1.15(+ ou -) 0.15 ml/g; biodisponibility: 0.19(+ ou -) 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300013aminoethyl pharmacokinetics |
| spellingShingle | M. H. Guerra Andrade A. C. T. Freire D. L. Nelson Pharmacokinetic profile of tert-butylaminoethanethiol Memorias do Instituto Oswaldo Cruz aminoethyl pharmacokinetics |
| title | Pharmacokinetic profile of tert-butylaminoethanethiol |
| title_full | Pharmacokinetic profile of tert-butylaminoethanethiol |
| title_fullStr | Pharmacokinetic profile of tert-butylaminoethanethiol |
| title_full_unstemmed | Pharmacokinetic profile of tert-butylaminoethanethiol |
| title_short | Pharmacokinetic profile of tert-butylaminoethanethiol |
| title_sort | pharmacokinetic profile of tert butylaminoethanethiol |
| topic | aminoethyl pharmacokinetics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300013 |
| work_keys_str_mv | AT mhguerraandrade pharmacokineticprofileoftertbutylaminoethanethiol AT actfreire pharmacokineticprofileoftertbutylaminoethanethiol AT dlnelson pharmacokineticprofileoftertbutylaminoethanethiol |