Exploratory Genome-Wide Association Analysis to Identify Pharmacogenetic Determinants of Response to R-CHOP in Diffuse Large B-Cell Lymphoma

Exploratory Genome-Wide Association Analysis to Identify Pharmacogenetic Determinants of Response to R-CHOP in Diffuse Large B-Cell Lymphoma

R-CHOP standard chemotherapy is successful in about 60% of diffuse large B-cell lymphoma (DLBCL) patients. Unresponsive patients have a poor prognosis, and predictive biomarkers of response to R-CHOP are lacking. We conducted the first prospective GWAS study aimed at exploring constitutional biomark...

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Bibliographic Details
Main Authors: Gabriele Perrone, Luigi Rigacci, Sara Urru, Sofya Kovalchuk, Marco Brugia, Alberto Fabbri, Lorenzo Iovino, Benedetta Puccini, Emanuele Cencini, Enrico Orciuolo, Silvia Birtolo, Alessandro Melosi, Simone Santini, Ida Landini, Giandomenico Roviello, Raffaella Santi, Alessandra Macciotta, Fulvio Ricceri, Alberto Bosi, Monica Bocchia, Mario Petrini, Enrico Mini, Stefania Nobili
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
diffuse large B-cell lymphoma
R-CHOP
predictive biomarkers
pharmacogenetics
single-nucleotide polymorphism
genome-wide association study
Online Access:https://www.mdpi.com/2072-6694/15/10/2753

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https://www.mdpi.com/2072-6694/15/10/2753

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