GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance

GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance

Skeletal muscle is an important tissue responsible for glucose and lipid metabolism. High-fat diet (HFD) consumption is associated with the accumulation of bioactive lipids: long chain acyl-CoA, diacylglycerols (DAG) and ceramides. This leads to impaired insulin signaling in skeletal muscle. There i...

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Bibliographic Details
Main Authors: Iwona Kojta, Piotr Zabielski, Kamila Roszczyc-Owsiejczuk, Monika Imierska, Emilia Sokołowska, Agnieszka Błachnio-Zabielska
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
insulin resistance
skeletal muscle lipid metabolism
gene silencing
shRNA
electroporation
Online Access:https://www.mdpi.com/1422-0067/21/19/7369

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