Design, Synthesis and Evaluation of Fused Bicyclo[2.2.2]octene as a Potential Core Scaffold for the Non-Covalent Inhibitors of SARS-CoV-2 3CL<sup>pro</sup> Main Protease

Design, Synthesis and Evaluation of Fused Bicyclo[2.2.2]octene as a Potential Core Scaffold for the Non-Covalent Inhibitors of SARS-CoV-2 3CL<sup>pro</sup> Main Protease

The emergence of SARS-CoV-2, responsible for the global COVID-19 pandemic, requires the rapid development of novel antiviral drugs that would contribute to an effective treatment alongside vaccines. Drug repurposing and development of new molecules targeting numerous viral targets have already led t...

Повний опис

Бібліографічні деталі
Автори: Barbara Herlah, Andrej Hoivik, Luka Jamšek, Katja Valjavec, Norio Yamamoto, Tyuji Hoshino, Krištof Kranjc, Andrej Perdih
Формат: Стаття
Мова:English
Опубліковано: MDPI AG 2022-04-01
Серія:Pharmaceuticals
Предмети:
bicyclo[2.2.2]octenes
molecular scaffolds
SARS-CoV-2
3CL<sup>pro</sup> main protease
COVID-19 antiviral drugs
Онлайн доступ:https://www.mdpi.com/1424-8247/15/5/539

Інтернет

https://www.mdpi.com/1424-8247/15/5/539

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