Fear response-based prediction for stress susceptibility to PTSD-like phenotypes
Abstract Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13041-020-00667-5 |
| _version_ | 1831653122077884416 |
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| author | Min-Jae Jeong Changhee Lee Kibong Sung Jung Hoon Jung Jung Hyun Pyo Joung-Hun Kim |
| author_facet | Min-Jae Jeong Changhee Lee Kibong Sung Jung Hoon Jung Jung Hyun Pyo Joung-Hun Kim |
| author_sort | Min-Jae Jeong |
| collection | DOAJ |
| description | Abstract Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mechanisms and functional implication remain unclear yet. We found that an increased amount of freezing that animals exhibited in the intertrial interval (ITI) of a stress-enhanced fear learning paradigm, predicts ensuing PTSD-like symptoms whereas resilient mice show ITI freezing comparable to that of unstressed mice. To examine the behavioral features, we developed a systematic analytical approach for ITI freezing and stress susceptibility. Thus, we provide a behavioral parameter for prognosis to stress susceptibility of individuals in the development of PTSD-like symptoms as well as a new mathematical means to scrutinize freezing behavior. |
| first_indexed | 2024-12-19T15:59:59Z |
| format | Article |
| id | doaj.art-8d0fbd20aa044945930984cbb83592f6 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-19T15:59:59Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-8d0fbd20aa044945930984cbb83592f62022-12-21T20:14:58ZengBMCMolecular Brain1756-66062020-10-011311910.1186/s13041-020-00667-5Fear response-based prediction for stress susceptibility to PTSD-like phenotypesMin-Jae Jeong0Changhee Lee1Kibong Sung2Jung Hoon Jung3Jung Hyun Pyo4Joung-Hun Kim5Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Mathematics, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Abstract Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mechanisms and functional implication remain unclear yet. We found that an increased amount of freezing that animals exhibited in the intertrial interval (ITI) of a stress-enhanced fear learning paradigm, predicts ensuing PTSD-like symptoms whereas resilient mice show ITI freezing comparable to that of unstressed mice. To examine the behavioral features, we developed a systematic analytical approach for ITI freezing and stress susceptibility. Thus, we provide a behavioral parameter for prognosis to stress susceptibility of individuals in the development of PTSD-like symptoms as well as a new mathematical means to scrutinize freezing behavior.http://link.springer.com/article/10.1186/s13041-020-00667-5PTSDStressFear conditioningITI |
| spellingShingle | Min-Jae Jeong Changhee Lee Kibong Sung Jung Hoon Jung Jung Hyun Pyo Joung-Hun Kim Fear response-based prediction for stress susceptibility to PTSD-like phenotypes Molecular Brain PTSD Stress Fear conditioning ITI |
| title | Fear response-based prediction for stress susceptibility to PTSD-like phenotypes |
| title_full | Fear response-based prediction for stress susceptibility to PTSD-like phenotypes |
| title_fullStr | Fear response-based prediction for stress susceptibility to PTSD-like phenotypes |
| title_full_unstemmed | Fear response-based prediction for stress susceptibility to PTSD-like phenotypes |
| title_short | Fear response-based prediction for stress susceptibility to PTSD-like phenotypes |
| title_sort | fear response based prediction for stress susceptibility to ptsd like phenotypes |
| topic | PTSD Stress Fear conditioning ITI |
| url | http://link.springer.com/article/10.1186/s13041-020-00667-5 |
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