Improving gene set enrichment analysis (GSEA) by using regulation directionality

Improving gene set enrichment analysis (GSEA) by using regulation directionality

ABSTRACTTo infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene is activated or repressed by a regulator. This dis...

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Bibliographic Details
Main Authors: Biwen Wang, Frans van der Kloet, Mariah B. M. J. Kes, Joen Luirink, Leendert W. Hamoen
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:Microbiology Spectrum
Subjects:
transcriptome analysis
GSEA
regulons
functional categories
Bacillus subtilis
operons
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03456-23

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